JBL XI: Oct. 2008

11th Annual John B. Little Symposium

“Cell and Genome Stability Mechanisms in Cancer and Other Diseases

October 24-25, 2008


Friday, October 24 2008

John B. Little Award Lecture given by Lawrence Loeb Ph.D.

Professor, Department of Biochemistry

University of Washington

“Mutator Phenotype in Human Cancer:  Origin and Consequences”

Session: I

Discussion Leader: Michael Makrigiorgos, Ph.D.

Associate Professor of Radiation Oncology, Department of Radiation Oncology

Dana-Farber Cancer Institute, Harvard Medical School

David E. Fisher, M.D., Ph.D.

Professor of Pediatrics/Chairman, Department of Dermatology and Director, Melanoma Program in Medical Oncology, Massachusetts General Hospital

Harvard Medical School

“UV, Skin Signaling, and Cutaneous Cancer Risk”

Frank McKeon, Ph.D.

Professor, Department of Cell Biology

Harvard Medical School

“TAp63: Maintaining the Superiority of the Female Germline”

Tanya Paull, Ph.D.

Professor, Department of Molecular Genetics and Microbiology 

University of Texas, Austin

“Mre11/Rad50 complexes and DNA double-strand break repair”

Craig Peterson, Ph.D.

Professor and Vice-Chair, Program in Molecular Medicine, University of Massachusetts Medical School

“Chromatin remodeling and genomic integrity”

Saturday October 25, 2008

Session II:

Discussion Leader: Andrew Grosovsky, Ph.D.

Professor of Cell Biology and Toxicology, Department of Biochemistry 

University of California, Riverside

Pamela Silver, Ph.D.

Professor, Department of Systems Biology

Harvard  Medical School

“Designing Biological Systems”

Myron Goodman, Ph.D.

Professor of Chemistry, Head of Molecular and Computational Biology

 University of Southern California

“Better Living Through Hyper-Mutation”

Thomas Kunkel, Ph.D.

Research Geneticist, 

National Institute of Environmental Health Sciences, NIH

“Division of Labor at Yeast DNA Replication Forks”

Graham Walker, Ph.D.

Professor, Department of Biology

Massachusetts Institute of Technology

“Dealing with DNA Problems: Template Lesions and Replication Blocks”

Session III:

Discussion Leader: Karl Kelsey, M.D.

Professor of Community Health, Bio Med Center for Environmental Health and Technology, Brown University

Raul Mostoslavsky, Ph.D.

Assistant Professor, Harvard Medical School, Assistant Geneticist, MGH Cancer Center, Department of Medicine, Massachusetts General Hospital

“The role of the chromatin factor SIRT6 in glucose homeostasis”

Brian Dynlacht, Ph.D.

Professor in the Department of Pathology, NYU School of Medicine, Director of Genomics Program, NYU Cancer Institute

“Regulation of Centrosome Duplication and Genome Stability”

Johannes Walter, Ph.D.

Associate Professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

“Mechanism of DNA Interstrand Cross-Link Repair in S Phase”