JBL XIII: Oct. 2010

13th Annual JBL Symposium

“Stress responses in radiobiology, cancer and aging”

October 22-23, 2010


Friday, October 22, 2010



Gökhan S. Hotamisligil, M.D., Ph.D.

Chair and J.S. Simmons Professor of Genetics and Metabolism

Department of Molecular Metabolism

Harvard School of Public Health

Julio Frenk, M.D., Ph.D.

Dean of the Faculty, Harvard School of Public Health 

T & G Angelopoulos Professor of Public Health and International Development

Harvard School of Public Health and Harvard Kennedy School

John B. Little, M.D.

James Stevens Simmons Professor of Radiobiology, Emeritus

Department of Molecular Metabolism,

Harvard School of Public Health

Discussion Leader: James R. Mitchell, Ph.D.

Assistant Professor, Department of Molecular Metabolism

Harvard School of Public Health

Chuan-Yuan Li, Ph.D.

Professor and Director of the Division of Radiation and Cancer Biology, University of Colorado, Denver; Professor of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO

“Phoenix Rising” and the “Wheel of Life”, redefining the roles of cellular apoptosis in multi-cellular organisms

Dipanjan Chowdhury, Ph.D.

Assistant Professor, Radiation Oncology

Department, Dana-Farber Cancer Institute; Assistant Professor, Department of Radiation Oncology, Harvard Medical School

“Regulation of DNA Double Strand Break (DSB) repair by microRNAs”

Barbara A. Gilchrest, M.D.

Professor and Chair-Emeritus, Department of Dermatology, Boston University School of Medicine

”Telomere-based SOS-like protective responses in mammalian cells”

Katharine Yen, Ph.D.Director, Biology, Agios Pharmaceuticals

“IDH Mutations and Tumorigenicity”

Ana Maria Cuervo, M.D., Ph.D.

Professor, Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Institute for Aging Research, Albert Einstein College of Medicine

”Selective autophagy on the cellular response to stress in aging”

Richard I. Morimoto, Ph.D.

Bill and Gayle Cook Professor of Biology, Department of Biochemistry, Molecular Biology and Cell Biology; Director, Rice Institute for Biomedical Research, Northwestern University

”Protecting the proteome from stress, aging, and disease”

Saturday, October 23, 2010

Discussion Leader: Marcia C. Haigis, Ph.D., Assistant Professor,

Department of Pathology, Harvard Medical School

Richard A. Miller, M.D., Ph.D.

Professor of Pathology, University of Michigan School of Medicine; Associate Director for Research, Geriatrics Center, University of Michigan; Research Scientist, Ann Arbor DVA Medical Center

“Cellular stress resistance and aging: from culture to critters all-sorts”

T. Keith Blackwell, M.D., Ph.D.

Associate Director of Research, Senior Investigator and co-head of the Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center; Professor of Pathology, Harvard Medical School

”Mechanisms through which growth signals affect stress resistance and aging in C. elegans”

Alec C. Kimmelman, M.D., Ph.D.

Assistant Professor of Radiation Oncology, Dana-Farber Cancer Institute; Harvard Medical School

”Pancreatic cancers rely on altered metabolic and cell survival pathways for tumor growth”

Valter D. Longo, Ph.D.

The Albert L. and Madelyne G. Hanson Family Trust Associate Professor in Gerontology,

Associate Professor in Biological Science, University of Southern California Los Angeles

”Differential stress resistance in cancer treatment”

Session III:

Discussion Leader: Zhi-Min Yuan, M.D., Ph.D.

Greehey Distinguished Chair and Professor Radiation Oncology, The University of Texas Health Science Center at San Antonio

Carmel Mothersill, B.Sc., Ph.D.

Professor, Medical Physics and Applied Radiation Sciences, McMasters University

“Bystander signaling as an evolutionarily concerved mechanism of stress communication within and between organisms”

Michael R. Ristow, M.D., Ph.D.

Chair and Professor of Nutrition, Department of Human Nutrition, University of Jena, Germany

”Promoting metabolic health and lifespan by increasing oxidative stress”

Siegfried Hekimi, Ph.D.

Robert Archibald & Catherine Louise Campbell Chair in Developmental Biology, Strathcona Professor of Zoology, Department of Biology, McGill University

“Mitochondrial ROS signaling moderates the rate of aging”