Professor of Bioengineering and Physiology
665 Huntington Avenue
Building I Room 313
Boston, MA 02115
Program in Molecular, Integrative and Physiological Sciences (MIPS)
BSME, 1968, Tufts University
Ph.D., 1973, Massachusetts Institute of Technology
Presentation Video: “Cell jamming and shape-shifting in collective cellular migration”. (2016.08.31 – Physical Sciences-Oncology Network at the National Cancer Institute, Rockville, MD)
Physics in biology – Physics in biology: soft cells. Nature; Physics Portal, September, 2001.
A cellular glass menagerie – A cellular glass menagerie, Geoff Brumfiel, Physical Review Focus, American Physical Society, 24 September, 2001.
Experiments Reveal How Cells Can Act Like Molten Glass – Experiments Reveal How Cells Can Act Like Molten Glass. Kristin Leutwyler, Scientific American. 2001
Clear as glass – Harvard Public Health Review. 2007
A stretch in the cells . Nature, 2007.
How growing cells move together. CC Morton, Harvard Science Foundations, 2009.
Our laboratory seeks to discover physical laws governing the abilities of the cytoskeleton to deform, contract, and remodel. These basic mechanical processes underlie a range of higher level phenomena in health and disease including many aspects of cancer, cardiovascular disease, malaria, and morphogenesis, but our major research emphasis is the role of these processes in airway narrowing in asthma. Trainees with backgrounds in engineering sciences, cell biology, or physics of soft condensed matter learn how to work side-by-side to pose new questions, invent new nanotechnologies, apply these technologies in novel experimental investigations, and analyze resulting data in terms of evolving mechanistic understanding of the physical properties of the living cell.
Journal covers featuring our work: