Jessica Howell

Research Fellow

Department of Genetics and Complex Diseases

Department of Genetics and Complex Diseases

Building 2, Room 131
655 Huntington Avenue
Boston, Massachusetts 02115


Ph.D., 2009, Rockefeller University

Research Interests

My research focuses on the elucidating of the layers of regulation that govern cellular functions, particularly those relevant to metabolic disease.  I am currently investigating transcriptional changes induced by loss of the Tsc genes and am exploring the role of mTOR repression in ameliorating the diabetic phenotype.

Select Publications

Silva JP, Howell J, von Meyenn F, Thorens B, Wolfrum C, Stoffel M.  Regulation of adaptive behavior during fasting by hypothalamic Foxa2.  Nature.  2009 Dec 3; 462(7273): 646-50.

Howell JJ, Stoffel M.  Nuclear export-independent inhibition of Foxa2 by insulin.  J Biol Chem.  2009 Sep 11; 284(37):24816-24.

Wolfrum C, Howell JJ, Ndungo E, Stoffel M.  Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M.  J Biol Chem. 2008 Jun 13; 283(24):16940-16949.

Arsham AM, Howell JJ, Simon MC.  A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.  J Biol Chem. 2003 Aug 8; 278(32):29655-60.