Publications

PubMed-NCBI 

  1. O’Sullivan MJ, Phung TN, Park JA. Bronchoconstriction: a potential missing link in airway remodelling. Open Biology. 2020 Dec;10(12):200254. Epub 2020 Dec 2.
  2. O’Sullivan MJ*, Mitchel JA*, Mwase C, McGill M, Kanki P, Park JA. In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2020, Nov 11.  Online ahead of print.(*equally contributed)
  3. Mitchel JA*, Das A*, O’Sullivan MJ, Stancil IT, DeCamp SJ, Koehler S, Ocaña OH, Butler JP, Fredberg JJ, Nieto MA, Bi D, Park JAIn primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition. Nature Communications, 2020, Oct 7. (*equally contributed)
  4. O’Sullivan MJ, Mitchel MA, Das A, Koehler S, Levine H, Bi D, Nagel ZD, Park JAIrradiation induces epithelial cell unjammingFrontiers in Cell and Developmental Biology, 2020 Feb 11;8:21.
  5. Kilic A*, Ameli A*, Park JA*, Kho AT, Tantisira K, Santolini M, Cheng F, Mitchel JA, McGill M, O’Sullivan MJ, De Marzio M, Sharma A, Scott Randell SH, Drazen JD, Jeffrey Fredberg JJ, Weiss ST. Mechanical forces induce an asthma gene signature in healthy airway epithelial cells. Scientific Reports, 2020, Jan 22;10(1):966.  (*equally contributed)
  6. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. GWAS Functional Variant rs2076295 Regulates Desmoplakin (DSP) Expression in Airway Epithelial Cells. American journal of respiratory and critical care medicine. 2020 Jun 18.
  7. Hou M, Han J, Li G, Kwon MY, Jiang J, Emani S, Taglauer ES, Park JA, Choi EB, Vodnala M, Fong YW, Emani SM, Rosas IO, Perrella MA, Liu X. Multipotency of Mouse Trophoblast Stem Cells, Stem Cell Research & Therapy, 2020 Feb 13;11(1):55.
  8. O’Sullivan MJ, Mitchel MA, Das A, Koehler S, Levine H, Bi D, Nagel ZD, Park JA. Irradiation induces epithelial cell unjamming. Frontiers in Cell and Developmental Biology, 2020;8:21.
  9. Kilic A*, Ameli A*, Park JA*, Kho AT, Tantisira K, Santolini M, Cheng F, Mitchel JA, McGill M, O’Sullivan MJ, De Marzio M, Sharma A, Scott Randell SH, Drazen JD, Jeffrey Fredberg JJ, Weiss ST. Mechanical forces induce an asthma gene signature in healthy airway epithelial cells. Scientific Reports, 2020 Jan 22;10(1):966. (*equally contributed)
  10. Kim JH, Pegoraro AF, Das A, Koehler SA, Ujwary SA, Lan B, Mitchel JA, Atia L, He S, Wang K, Bi D, Zaman MH, Park JA, Butler JP, Lee KH, Starr JR, Fredberg JJ. Unjamming and collective migration in MCF10A breast cancer cell lines. Biochem Biophys Res Commun. 2020 Jan 15;521(3):706-715.
  11. Kim SH, Mitchel JA, McGill M, Cremona TP, Baek J, Kasahara DI, Anathy V, Israel E, Park JA. Elevated extracellular maspin after mechanical compression in vitro or allergen challenges in vivo. Journal of Allergy and Clinical Immunology. 2019 Oct;144(4):1116-1118.e4. PMID: 31228474
  12. Park HR, O’Sullivan M, Vallarino J, Shumyatcher M, Himes BE, Park JA, Christiani DC, Allen J, Lu Q. Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes. Scientific reports. 2019; 9(1):1400.
  13. He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA,  Park JA, Butler JP, Lu Q, Fredberg JJ. The tumor suppressor p53 can promote collective cellular migration. PloS one. 2019; 14(2): e0202065.
  14. Barrios J, Kho AT, Aven L, Mitchel JA, Park JA, Randell SH, Miller LA, Tantisira KG, Ai X. Pulmonary Neuroendocrine cells secrete GABA to induce goblet cell hyperplasia in primate models. American journal of respiratory cell and molecular biology. 2019;60(6):687-694.
  15. Grainge C, Park JA. Inflammatory insights into airway changes in asthma. Respirology (Carlton, Vic.). 2018; 23(12):1084-1085.
  16. Lan B, Mitchel JA, O’Sullivan MJ, Park CY, Kim JH, Cole WC, Butler JP, Park JA. Airway epithelial compression promotes airway smooth muscle proliferation and contraction. American Journal of Physiology: Lung Cellular and Molecular Physiology
  17. Glass K, Thibault D, Guo F, Mitchel JA, Pham B, Qiu W, Li Y, Jiang Z, Castaldi PJ, Silverman EK, Raby B, Park JA, Yuan GC, Zhou X. Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke. Scientific reports. 2018; 8(1):12750.
  18. Atia L, Bi D, Sharma A, Mitchel JA, Gweon B, Koehler SA, DeCamp SJ, Lan B, Kim JH, Hirsch R, Pegoraro AF, Lee KH, Starr JR, Weitz DA, Martin AC, Park JA, Butler JP, Fredberg JJ. Geometric constraints during epithelial jamming. Nature Physics 2018; 14:613-620.
  19. Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes B, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore SA, Park JA, Weiss ST, Wu AC, Lu Q. A Functional Asthma Variant in the Human Gasdermin B (GSDMB) Gene. Journal of Allergy and Clinical Immunology. 2018; 142(5):1469-1478.e2.
  20. Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Paré PD, Fredberg JJ, Smith MA. The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS One. 2017 Mar 9;12(3):e0171728.
  21. Park JA, Atia L, Mitchel JA, Fredberg JJ, Butler JP. Collective migration and cell jamming in asthma, cancer and development. Journal of Cell Science. 2016 Sep 15;129(18):3375-83.
  22. Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Hsu YH, Mathews JA, Kasahara DI, Park JA, Bordini A, Godleski JJ, Gillis BS, Brain JD. Repeated mouse lung exposures to Stachybotrys chartarum shift immune response from type 1 to type 2. American Journal of Respiratory Cellular and Molecular Biology. 2016 Oct;55(4): 521-531.
  23. Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Kasahara DI, Randell SH, Israel E, Shore SA, Mackman N, Park JA. IL-13 augments compressive stress-induced tissue factor expression in human airway epithelial cells. American Journal of Respiratory Cellular and Molecular Biology. 2016. Apr;54(4):524-31.
  24. Park JA, Fredberg JJ. Cell jamming in the airway epithelium. Annals of the American Thoracic Society. 2016. Mar;13 Suppl 1:S64-7.
  25. Krishnan R, Park JA.Wadsworth S, Seow S, Lee P, Seow A. Cellular biomechanics in drug screening and evaluation: Mechanopharmacology. Trends in Pharmacological Sciences.  2015 Dec 1. pii: S0165-6147(15)00224-2. doi: 10.1016/j.tips.2015.10.005. [Epub ahead of print]
  26. Pegoraro AF, Fredberg JJ, Park JA. Problems in biology with many scales of length: Cell-cell adhesion and cell jamming in collective cellular migration. Experimental Cell Research. 2015 Nov 3. pii: S0014-4827(15)30138-5. doi: 10.1016/j.yexcr.2015.10.036. [Epub ahead of print]
  27. Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Randell SH, Israel E, Shore SA, Mackman N, Park JA. IL-13 augments compressive stress-induced tissue factor expression in human airway epithelial cells. American Journal of Respiratory Cellular and Molecular Biology. Sep 25. 2015 [Epub ahead of print]
  28. Park JA†*, Kim JH*, Bi D, Mitchel JA, Qazvini NT, Tantisira K, Park CY, McGill M, Kim SH, Gweon B, Notbohm J, Steward R, Burger B, Randell SH, Kho AT, Tambe DT, Hardin C, Shore SA, Israel E, Weitz DA, Tschumperlin DJ, Henske EP, Weiss ST, Manning ML, Butler JP, Drazen JM, Fredberg JJ. Unjamming and cell shape in the asthmatic airway epithelium. (†corresponding author, *equally contributed) Nature Materials. Oct. 14(10):1040-8. 2015.        Access the recommendation on F1000Prime   http://f1000.com/prime/725694357?bd=1  
  29. Park JA, Fredberg JJ, Drazen JM. Putting the squeeze on airway epithelia. Physiology. July; 30(4): 293-303, 2015.
  30. Kim JH, Serra-Picamal X, Tambe DT, Zhou EH, Park CY, Sadati M, Park JA, Krishnan R, Gweon B, Millet E, Butler JP, Trepat X, Fredberg JJ. Propulsion and navigation within the advancing monolayer sheet. Nature Materials. 12(9):856-63. 2013.
  31. Park JA, Sharif AS, Shiomi T, Kobzik L, Kasahara DI, Tschumperlin DJ, Voynow JA, Drazen JM. Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. American Journal of Physiology: Lung Cellular and Molecular Physiology. 304(10):L701-7. 2013.
  32. Park JA, Sharif AS, Tschumperlin DJ, Lau L, Limbrey R, Howarth PH, Drazen JM. TF-bearing exosomes from mechanically-stimulated human bronchial epithelial cells in vitro and in vivo. Journal of Allergy and Clinical Immunology. 130(6):1375-83. 2012.
  33. Marinkovic A, Mih J, Park JA, Liu F, Tschumperlin DJ. Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness. American Journal of Physiology: Lung Cellular and Molecular Physiology. 303(3):L169-80. 2012.
  34. Shiomi T, Tschumperlin DJ, Park JA, Sunnarborg SW, Horiuchi K, Blobel CP, Drazen JM. TACE/ADAM17 mediates mechanotransduction in murine tracheal epithelial cells. American Journal of Respiratory Cellular and Molecular Biology 45(2):376-85. 2011.
  35. Park JA, Drazen JM, Tschumperlin DJ. The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. Journal of Biological Chemistry 285(39): 29817-25, 2010.
  36. Kojic N, Chung E, Kho AT, Park JA, Huang A, So PT, Tschumperlin DJ. An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium. FASEB J. 24(5): 1604-15, 2010.
  37. Park JA, Tschumperlin DJ. Chronic intermittent Mechanical Stress Increases MUC5AC Protein Expression. Am J Respir Cell Mol Biol. 41(4): 459-66, 2009.
  38. Park JA, Crews AL, Lampe WR, Fang S, Park J, Adler KB. Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein. American Journal of Pathology. 171(6):1822-30, 2007.
  39. Park JA, Adler KB. Potential therapy for mucus hypersecretion in chronic obstructive pulmonary disease. Zhonghua Yi Xue Za Zhi. 86(41):2890-2, 2006.
  40. Chorley BN, Li Y, Fang S, Park JA, Adler KB. (R)-albuterol elicits anti-inflammatory effects in human airway epithelial cells via iNOS. American Journal of Respiratory Cellular and Molecular Biology. 34(1): 119-127, 2006.
  41. Park JA, He F, Martin LD, Li Y, Chorley BN, Adler KB. Human Neutrophil Elastase Induces Hypersecretion of Mucin from Well-Differentiated Human Bronchial Epithelial Cells in vitro via a Protein Kinase C delta – Mediated Mechanism. American Journal of Pathology. 167(3): 651-661, 2005.

Book Chapter

Park JA, Crews AL, Raiford KL, Adler KB. Chapter 11: Mucus and mucus-secreting cells in chronic obstructive pulmonary disease. Chronic Obstructive Lung Disease. 2nd edition, editors: Norbert Voelkel and William MacNee. p141-151, 2008.