Johan Spetz, PhD

Postdoctoral Fellow, 2017 – Present

Graduate Degree: University of Gothenburg (Gothenburg, Sweden)

Johan’s Publications from the Sarosiek Laboratory:

Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX.
Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Abigail Cleveland, Nicole Almanzar, Chuan Bian Lim, Gaurav Joshi, Johan Spetz, Xingping Qin, Sneh Toprani, Zachary Nagel, Matthew C Hocking, Robert A Cormack, Torunn I Yock, Jeffrey W Miller, Zhi-Min Yuan, Timothy Gershon, Kristopher Sarosiek.
Cancer Research, 2023 October 13. PDF. External.
Targeting TBK1 to overcome resistance to cancer immunotherapy.
Yi Sun, Or-yam Revach, Seth Anderson, Emily A. Kessler, Clara H. Wolfe, Anne Jenney, Caitlin E. Mills, Emily J. Robitschek, Thomas G. R. Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P. Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M. Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A. Michaud, Rodrigo Saad-Beretta, Kathleen B. Yates, Arvin Iracheta-Vellve, Johan Spetz, Xingping Qin, Kristopher Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y. Su, Angelina M. Cicerchia, Martin Q. Rasmussen, Samuel J. Klempner, Dejan Juric, Sara I. Pai, David M. Miller, Anita Giobbie-Hurder, Jonathan H. Chen, Karin Pelka, Dennie T. Frederick, Susanna Stinson, Elena Ivanova, Amir R. Aref, Cloud P. Paweletz, David A. Barbie, Debattama R. Sen, David E. Fisher, Ryan B. Corcoran, Nir Hacohen, Peter K. Sorger, Keith T. Flaherty, Genevieve M. Boland, Robert T. Manguso & Russell W. Jenkins
Nature, 2023 January 12. External.
Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities.
Johan Spetz, Kiwi Florido, Cameron Fraser, Xingping Qin, Jonathan Choiniere, Stacey Yu, Rumani Singh, Max Friesen, Lee L. Rubin, Joe-Elie Salem, Javid J. Moslehi, Kristopher Sarosiek.
Science Advances, 2022 November 11. PDF. External.
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics.
Cameron Fraser, Johan Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N. Hata, Jeffrey W. Miller, Gary A. Bradshaw,
Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek (co-corresponding author), Kristopher Sarosiek.
Nature Communications, 2022 Oct 2. PDF. Pubmed.
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.
Zintis Inde, Ben A. Croker (co-first author), Clarence Yapp, Gaurav Joshi, Johan Spetz, Cameron Fraser, Xingping Qin, Le Xu, Brian Deskin, Elisa Ghelfi, Gabrielle Webb, Aaron F. Carlin, Yangfei Peipei Zhu, Sandra Leibel, Aaron F. Garretson, Alex E. Clark, Jason M. Duran, Victor Pretorius, Laura E. Crotty-Alexander, Chendi Li, Jamie Casey Lee, Chhinder Sodhi, David J. Hackam, Xin Sun, Aaron Hata, Lester Kobzik, Jeffrey Miller, Jin-Ah Park, Douglas Brownfield, Hongpeng Jia, Kristopher A. Sarosiek.
Science Advances, August 18, 2021. PDF. PubMed.

Zintis Inde, Clarence Yapp, Gaurav Joshi, Johan Spetz, Cameron Fraser, Brian Deskin, Elisa Ghelfi, Chhinder Sodhi, David J. Hackam, Lester Kobzik, Ben A. Croker, Douglas Brownfield, Hongpeng Jia, Kristopher A. Sarosiek. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity (Preprint).
BioRxiv, September 13, 2020. PDF. BioRxiv.

Johan Spetz, Adam Presser, Kristopher A. Sarosiek.
T Cells and Regulated Cell Death: Kill or Be Killed (Review).
International Review of Cell and Molecular Biology, 2018 September. PDF. Pubmed.

Johan Spetz, Javid Moslehi, Kristopher A. Sarosiek.
Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment (Review).
Current Treatment Options in Cardiovascular Medicine, 2018 April (20:31). PDF. Pubmed.