Jie (Jack) Hu, M.D., Ph.D.

Postdoctoral Research Fellow
Center for Genomic Medicine and Department of Anaesthesia, Massachusetts General Hospital and Harvard Medical School; Department of Epidemiology, Harvard T.H. Chan School of Public Health

2020-present. Jack is a research fellow in the Saxena Lab in the Center for Genomic Medicine and Department of Anaesthesia at Massachusetts General Hospital and Harvard Medical School. He joined my research group as a postdoctoral research fellow in 2020 when he was a research fellow in the Division of Women’s Health at Brigham and Women’s Hospital (PI: Dr. Kathryn Rexrode). Jack obtained his MD from Tongji Medical College and his PhD from the School of Public Health at Huazhong University of Science and Technology, China.

Jack has rich research experience in maternal and child health, women’s health, and environmental health. He is interested the etiology of adverse pregnancy outcomes and their long-term impact on cardiometabolic health in women and their children. Jack’s current research utilizes large-scale, multi-omics data, under the framework of systems epidemiology, to identify novel risk factors and the underlying mechanisms of adverse pregnancy outcomes and cardiometabolic diseases in women, as well as to examine the (epi)genetic and metabolic bases of the intergenerational link in cardiometabolic disease risk. His research also extends to study the origin and mechanisms of sex and race differences in cardiometabolic disease risk.

Jack is actively leading or participating in multiple consortium metabolomics and (epi)genetics projects in the Trans-Omics for Precision Medicine (TOPMed), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), and COnsortium of METabolomics Studies (COMETS).

Jack’s research has been recognized by multiple awards, including:

  • Trudy Bush Fellowship for Cardiovascular Disease Research in Women’s Health (2018, American Heart Association)
  • Semi-finalist, Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research (Hu et al., Liang. Sexual dimorphism in genetic associations of testosterone and sex-hormone binding globulin with cardiometabolic diseases. 2019, American Society of Human Genetics)
  • Connors-BRI Research Recognition Award (Hu et al., Liang. Sex differences in the intergenerational link between maternal and neonatal whole blood DNA methylation: An analysis in the Boston Birth Cohort. 2021, Brigham and Women’s Hospital)

Jack’s research in the news: New ACC/AHA High Blood Pressure Guidelines Could Increase Detection of Gestational Hypertension (https://www.brighamandwomens.org/about-bwh/newsroom/research-briefs-detail?id=3364).