Predicting polycystic ovary syndrome with machine learning algorithms from electronic health records.
Zad Z, Jiang VS, Wolf AT, Wang T, Cheng JJ, Paschalidis IC, Mahalingaiah S.
Front Endocrinol (Lausanne). 2024. 15:1298628. PMID: 38356959
Faculty Affiliate in the Department of Epidemiology
Epidemiology
Harvard T.H. Chan School of Public Health
Assistant Professor of Obstetrics, Gynecology and Reproductive Biology, Part-time
Obstetrics Gynecology & Reproductive Bio. - MGH
Harvard Medical School
Shruthi Mahalingaiah is an assistant professor of environmental, reproductive, and women’s health in the Department of Environmental Health at the Harvard T.H. Chan School of Public health. She serves clinically as a physician specializing in ovulation disorders, reproductive endocrinology and infertility at the Massachusetts General Hospital in the Department of Obstetrics and Gynecology.
Research
Dr. Mahalingaiah’s research seeks to understand the association of environmental and modifiable risk factors on human reproduction as they pertain to the etiology and prevention of gynecological disease. Through physiology-informed research, she focuses on identifying environmental exposures associated with the development of polycystic ovary syndrome (PCOS) and metabolic sequelae. Her research encompasses three distinct areas: 1.) Air pollution and gynecologic disease incidence including cardiometabolic risk across the reproductive lifespan; 2.) Environmental toxicant exposures in the perinatal, perimenarchal, and adult time window with placental disease and ovulatory disorders; and 3.) Creation of diverse cohorts to study women’s health across the reproductive lifespan. She is currently funded by the March of Dimes, National Science Foundation, and is on the leadership team of the Apple Women’s Health study.
She was awarded the 2016 Endocrine Society Early Investigator award, an Ellison Family Foundation award, and an RSDP seed grant in 2017–2018 to create a pilot online study of ovulation and menstruation health. Supported by a Thomas J. Watson III Fellowship, she lived with indigenous shamans in the Ecuadorian Amazon Basin, Andes mountains, and Bali studying the role of ritual in the healing process. She was previously supported by K level funding from the Building Interdisciplinary Research Careers in Women’s’ Health (BIRCWH 2011–2014) and the Reproductive Scientist Development Program (RSDP 2104–2017) to study environmental exposures and incidence of benign gynecologic conditions.
Education
Dr. Mahalingaiah holds a BA from Middlebury College, an MD from Harvard Medical School, and an MS in epidemiology from Boston University’s School of Public Health. Prior to joining the Harvard Chan School, Dr. Mahalingaiah completed an OB/GYN residency at the Massachusetts General/Brigham and Women’s Hospital (MGH/BWH) combined program. She was a fellow in reproductive endocrinology and infertility at BWH which led to her appointment as an assistant professor of reproductive endocrinology and infertility in the Department of Obstetrics and Gynecology at Boston Medical Center and Boston University School of Medicine to serve the fertility aspirations of under-resourced populations. In 2016, she was appointed assistant professor in the department of epidemiology at Boston University School of Public Health and was appointed assistant professor in the department of physiology and biophysics at the Boston University School of Medicine the following year.
Zad Z, Jiang VS, Wolf AT, Wang T, Cheng JJ, Paschalidis IC, Mahalingaiah S.
Front Endocrinol (Lausanne). 2024. 15:1298628. PMID: 38356959
Fitz V, Graca S, Mahalingaiah S, Liu J, Lai L, Butt A, Armour M, Rao V, Naidoo D, Maunder A, Yang G, Vaddiparthi V, Witchel SF, Pena A, Spritzer PM, Li R, Tay C, Mousa A, Teede H, Ee C.
J Clin Endocrinol Metab. 2024 Jan 02. PMID: 38163998
Li H, Curry CL, Fischer-Colbrie T, Onnela JP, Williams MA, Hauser R, Coull BA, Jukic AMZ, Mahalingaiah S.
Int J Hyg Environ Health. 2024 Mar. 256:114308. PMID: 38103472
Adnan T, Li H, Peer K, Peebles E, James K, Mahalingaiah S.
J Med Internet Res. 2023 10 27. 25:e42164. PMID: 37889545
Aguilera J, Konvinse K, Lee A, Maecker H, Prunicki M, Mahalingaiah S, Sampath V, Utz PJ, Yang E, Nadeau KC.
Semin Perinatol. 2023 12. 47(8):151838. PMID: 37858459
Zad Z, Jiang VS, Wolf AT, Wang T, Cheng JJ, Paschalidis IC, Mahalingaiah S.
medRxiv. 2023 Oct 01. PMID: 37577593
Minis E, Stanford FC, Mahalingaiah S.
Curr Opin Endocrinol Diabetes Obes. 2023 12 01. 30(6):273-279. PMID: 37678163
Li H, Gibson EA, Jukic AMZ, Baird DD, Wilcox AJ, Curry CL, Fischer-Colbrie T, Onnela JP, Williams MA, Hauser R, Coull BA, Mahalingaiah S.
NPJ Digit Med. 2023 May 29. 6(1):100. PMID: 37248288
Chan M, Preston EV, Fruh V, Quinn MR, Hacker MR, Wylie BJ, O'Brien K, Williams PL, Hauser R, James-Todd T, Mahalingaiah S.
Environ Res. 2023 05 15. 225:115583. PMID: 36868449
Mahalingaiah S.
Curr Opin Endocrinol Diabetes Obes. 2022 Dec 01. 29(6):513. PMID: 36300290
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