The Manning lab, led by Brendan D. Manning Ph.D., is focused on defining the regulation and function of the PI3K-mTOR signaling network under both physiological and pathological settings.  To do so, a multi-tiered program of hypothesis-driven approaches utilizing genetics, biochemistry, cell biology, and animal models combined with unbiased systems-level tools, including genomics, proteomics, metabolomics, and bioinformatics, is employed. The lab’s research aims are based on the premise that delineating the complex circuitry of signaling networks within cells will provide insight into how best to directly stimulate or inhibit these pathways, as appropriate, for the prevention or treatment of human diseases, including cancer and type-2 diabetes.