hunink

Maria Hunink

Adjunct Professor of Health Policy

Department of Health Policy and Management

Brief CV

Myriam Hunink, MD, PhD received her MD degree from the University of Leiden, trained as a radiologist in Amsterdam, and received her PhD degree in clinical decision analysis from the Erasmus University Rotterdam. Subsequently, she did subspecialty training in cardiovascular radiology at Brigham and Women’s Hospital/Harvard Medical School in Boston and a research fellowship in decision sciences at Harvard School of Public Health.

After some time as Assistant Professor in Decision Sciences at Harvard School of Public Health she was awarded a prestigious grant in the Netherlands that enticed her to return and accept a position as Associate Professor at the University of Groningen.

Currently she is Professor of Clinical Epidemiology and Radiology at the Erasmus university Medical Center Rotterdam, the Netherlands and Adjunct Professor of Health Policy at the Harvard School of Public Health, Boston.

Education

1995 Board-certification Epidemiology

1988 Board-certification Radiology

1989 PhD (decision analysis), Erasmus University Rotterdam

1984 MD, Leiden University

1980 BSc (applied mathematics), Leiden University

 

Research

Dr. Hunink’s research focuses on the assessment of diagnostic imaging and image-guided therapeutic technologies, using techniques from clinical epidemiology, metaanalysis, decision modeling, and cost-effectiveness analysis. Her main interests are in cardiovascular disease and trauma imaging. Methodological issues of special interest to her are study designs for the evaluation of diagnostic imaging and stochastic modeling.

 

Publications

Monographs

Hunink MGM, Glasziou PP, Siegel JE, Weeks JC, Pliskin JS, Elstein AS, Weinstein MC. Decision Making in Health and Medicine: Integrating Evidence and Values.
Cambridge University Press, Cambridge, UK, 2001 (978-0521770293)
(also translated into Japanese)

Selected publications

Cardiovascular

1.    Hunink MGM, Wong JB, Donaldson MC, Meyerovitz MF, De Vries JA, Harrington DP. Revascularization for femoropopliteal arterial disease: a decision and cost-effectiveness analysis. JAMA 1995; 274: 165-171.

2.    Hunink MGM, Goldman L, Tosteson ANA, Mittleman MA, Goldman PA, Williams LW, Tsevat J, Weinstein MC. The recent decline in mortality from Coronary Heart Disease, 1980-1990: The effect of secular trends in risk factors and treatment.  JAMA  1997; 277: 535-542.

3.      Fleischmann KE, Hunink MGM, Kuntz KM, Douglas PS.  Exercise echocardiography or exercise SPECT imaging? A meta-analysis of diagnostic test performance. JAMA 1998; 280: 913-920.

4.     Kuntz KM, Fleischmann KE, Hunink MGM, Douglas PS. Cost-effectiveness of diagnostic strategies for patients with chest pain. Ann Intern Med 1999; 130:709-718.

5.      Hunink MGM, Kuntz KM, Fleischmann KE, Brady TJ. Noninvasive imaging for the diagnosis of coronary artery disease: focusing the development of new diagnostic technology. Ann Intern Med 1999; 131: 673-680.

6.      Muradin GSR, Hunink MGM. Cost and Patency Rate Targets for the Development of Endovascular Devices to Treat Femoropopliteal Arterial Disease. Radiology 2001; 218: 464-469.

7.       de Vries SO, Visser K, de Vries JA, Wong JB, Donaldson MC, Hunink MGM. Intermittent claudication: cost-effectiveness of revascularization versus exercise therapy. Radiology 2002; 222: 25-36.

8.       Hunink MGM, Krestin GPK. Study design for the concurrent development, assessment,
and implementation of new diagnostic imaging technology. Radiology 2002; 222(3): 604-14.

9.       Gaspoz JM, Coxson PG, Goldman PA, Williams LW, Kuntz KM, Hunink MGM, Goldman L. Cost-effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease. New Engl J Med 2002; 346: 1800-6.

10.   Liem YS, Kock MCJM, Ijzermans JNM, Weimar W, Visser K, Hunink MGM. Living renal donors: optimizing the imaging strategy –  Decision- and cost-effectiveness analysis. Radiology 2003;226:53-62.

11.    Visser K, Kock MCJM, Kuntz KM, Donaldson MC, Gazelle SG, Hunink MGM. Cost-effectiveness targets for multidetector row CT angiography in the work-up of patients with intermittent claudication. Radiology 2003; 227: 647-656.

12.   Nederkoorn PJ, van der Graaf Y, Hunink MGM. Duplex Ultrasound and MR Angiography compared to Digital Subtraction Angiography in Carotid Artery Stenosis: A Systematic Review. Stroke. 2003 May; 34(5):1324-32.

13.   Buskens E, Nederkoorn PJ, Buijs-van der Woude T, Mali WPThM, Kappelle LJ, Eikelboom BC, van der Graaf Y, Hunink MGM. Imaging of Carotid Arteries in symptomatic patients: Cost-Effeciveness of diagnostic strategies. Radiology 2004; 233(1):101-12.

14.   Spronk S, Bosch JL, Veen HF, den Hoed PT, Hunink MG. Intermittent claudication: functional capacity and quality of life after exercise training or percutaneous transluminal angioplasty–systematic review. Radiology 2005; 235(3):833-42.

15.   Kock MCJM, Adriaensen MEAPM, Pattynama PMT, van Sambeek MRHM, van Urk H, Stijnen T, Hunink MGM. DSA versus multi-detector row CT angiography in peripheral arterial disease: randomized controlled trial. Radiology 2005; 237(2):727-37.

16.   Ouwendijk R, de Vries M, Pattynama PMT,van Sambeek MRHM, de Haan MW, Stijnen T, van Engelshoven JMA, Hunink MGM. Imaging peripheral arterial disease: a randomized controlled trial comparing contrast-enhanced MR angiography and multi-detector row CT angiography. Radiology 2005; 236(3):1094-103.

17.   de Vries M, Ouwendijk R, Flobbe K, Nelemans PJ, Kessels AG, Schurink GH, van der Vliet JA, Heijstraten FM, Cuypers PW, Duijm LE, van Engelshoven JM, Hunink MG, de Haan MW. Peripheral arterial disease: clinical and cost comparisons between duplex US and contrast-enhanced MR angiography–a multicenter randomized trial. Radiology 2006;240(2):401-10.

18.   Ouwendijk R, de Vries M, Stijnen T, Pattynama PM, van Sambeek MR, Buth J, Tielbeek AV, van der Vliet DA, SchutzeKool LJ, Kitslaar PJ, de Haan MW, van Engelshoven JM, Hunink MG. Multicenter randomized controlled trial of the costs and effects of noninvasive diagnostic imaging in patients with peripheral arterial disease: The DIPAD Trial. AJR 2008 May;190(5):1349-57.

19.   Heijenbrok-Kal MH, Kock MC, Hunink MG. Lower Extremity Arterial Disease: Multidetector CT Angiography Meta-Analysis. Radiology. 2007 Nov;245(2):433-9.

20.   Heijenbrok-Kal MH, Nederkoorn PJ, Buskens E, van der Graaf Y, Hunink MGM. Diagnostic performance of duplex ultrasound in patients suspected of carotid artery disease: the ipsilateral versus contralateral artery. Stroke 2005; 36(10):2105-9.

21.   Heijenbrok-Kal MH, Buskens E, Nederkoorn PJ, van der Graaf Y, Hunink MGM. Optimal Peak Systolic Velocity Threshold at Duplex US for Determining the Need for Carotid Endarterectomy: A Decision Analytic Approach.  Radiology 2006; 238(2):480-8.

22.   Nijhuis RL, Stijnen T, Peeters A, Witteman JC, Hofman A, Hunink MG. Apparent and Internal Validity of a Monte Carlo-Markov Model for Cardiovascular Disease in a Cohort Follow-up Study. Med Decis Making 2006;26(2):134-44.

23.   Liem YS, Wong JB, Hunink MGM, De Charro FTh, Winkelmayer WC. Comparison of hemodialysis and peritoneal dialysis survival in the Netherlands. Kidney Int 2007; 71(2): 153-8

24.   van Helvoort-Postulart D, Dirksen CD, Nelemans PJ, Kroon AA, Kessels AG, de Leeuw PW, Vasbinder GB, van Engelshoven JM, Hunink MG. Renal artery stenosis: cost-effectiveness of diagnosis and treatment. Radiology. 2007 Aug;244(2):505-13.

25.  Pugliese F, Weustink AC, Van Mieghem C, Alberghina F, Otsuka M, Meijboom WB, Van Pelt N, Mollet NR, Cademartiri F, Krestin GP, Hunink MG, de Feyter PJ. Dual-source coronary computed tomography angiography for detecting in-stent restenosis. Heart. 2007 Sep 19

26.  Heijenbrok-Kal MH, Fleischmann KE, Hunink MG. Stress echocardiography, stress single-photon-emission computed tomography and electron beam computed tomography for the assessment of coronary artery disease: a meta-analysis of diagnostic performance.
Am Heart J. 2007 Sep;154(3):415-23.

27.   Vanhoenacker PK, Heijenbrok-Kal MH, Van Heste R, Decramer I, Van Hoe LR, Wijns W, Hunink MG. Diagnostic performance of multidetector CT angiography for assessment of coronary artery disease: meta-analysis. Radiology. 2007 Aug;244(2):419-28.

 

Trauma imaging

28.   Oei EHG, Nikken JJ, Verstijnen ACM, Ginai AZ, Hunink MGM. MR Imaging of the menisci and cruciate ligaments: a systematic review. Radiology 2003; 226(3):837-48.

29.   Nikken JJ, Oei EHG, Ginai AZ, Krestin GP, Verhaar JAN, van Vugt AB, Hunink MGM. Acute peripheral joint injury: cost and effectiveness of low-field-strength MR imaging–results of randomized controlled trial. Radiology 2005; 236(3):958-67.

30.   Hunink MGM. Decision making in the face of uncertainty and resource constraints: examples from trauma imaging. Radiology 2005; 235(2):375-83.

31.   Smits M, Dippel DW, de Haan GG, Dekker HM, Vos PE, Kool DR, Nederkoorn PJ, Hofman PA, Twijnstra A, Tanghe HL, Hunink MGM. External validation of the Canadian CT Head Rule and the New Orleans Criteria for CT scanning in patients with minor head injury. JAMA 2005; 294(12):1519-25.

32.  Smits M, Dippel DW, Steyerberg EW, de Haan GG, Dekker HM, Vos PE, Kool DR, Nederkoorn PJ, Hofman PA, Twijnstra A, Tanghe HL, Hunink MG. Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: the CHIP prediction rule. Ann Intern Med 2007 Mar 20;146(6):397-405.

33. Smits M, Dippel DW, de Haan GG, Dekker HM, Vos PE, Kool DR, Nederkoorn PJ, Hofman PA, Twijnstra A, Tanghe HL, Hunink MG. Minor head injury: guidelines for the use of CT -a multicenter validation study. Radiology 2007 Dec; 245 (3): 831-8.

Methodological

34.     Hunink MGM, Bult JR, De Vries JA, Weinstein MC. Uncertainty in decision models analyzing cost-effectiveness: The joint distribution of incremental costs and effectiveness evaluated with a non-parametric bootstrap method. Med Decis Making 1998; 18: 337-346.

35.   Hunink MGM, Gazelle SG. CT screening: a trade-off of risks, benefits, and costs. J Clin Invest 2003; 111(11):1612-9.

36.   Groot Koerkamp B, Hunink MGM, Stijnen T, Weinstein MC. Identifying key parameters in cost-effectiveness analysis using value of information: a comparison of methods. Health Econ. 2006 Apr;15(4):383-92.

37.   Groot Koerkamp B, Hunink MG, Stijnen T, Hammitt JK, Kuntz KM, Weinstein MC. Limitations of Acceptability Curves for Presenting Uncertainty in Cost-Effectiveness Analysis. Med Decis Making. 2007 March-April;27(2):101-111.

38.   Groot Koerkamp B, Nikken JJ, Oei EH, Stijnen T, Ginai AZ, Hunink MG, Value of information analysis used to determine the necessity of additional research: MR imaging in acute knee trauma as an example. Radiology 2008 Feb; 246(2): 420-5.