P2: EV miRs in cognitive function decline associated with early life metal exposure

Co-Leaders: Quan Lu and Takao Hensch Early-life exposure to environmental metal toxicants is associated with worse cognitive function in aging and may contribute to the development of neurodegenerative diseases, such as Alzheimer’s disease; however, the underlying molecular mechanisms remain poorly understood. This project conducts laboratory-based mechanistic studies to unravel critical biological pathways that contribute to cognitive aging associated with exposures to environmental metal contaminants. This study could lead to novel…

P3: Spatial patterns of metals and metal mixtures in drinking water

Leader: Elsie Sunderland Improved exposure and risk assessment methods, particularly for heavy metal mixtures in private wells surrounding Superfund sites, and information on the field-effectiveness of water treatment technology are needed to manage contaminated site remediation goals and develop drinking water guidance. This project will develop a novel statistical tool to forecast the contribution of Superfund sites to heavy metal mixtures in private wells and will evaluate the effectiveness of…

P4: Designing the next generation of highly selective sorbent materials for remediation of target inorganic contaminants in aqueous systems

Co-Leaders: Julie Zimmerman and Christopher Muhich Removing pollutants from contaminated drinking water is critical for public health, but traditional approaches to sorption of pollutants are insufficiently selective towards remove arsenic, chromium or selenium. We propose to revolutionize sorbent design by combining novel polymer and nano-science technologies with quantum mechanical simulations, machine learning, and molecular mass transport models. The proposed approach will lead to new selective sorbent materials for a variety…