Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion

In a recent publication in The Journal of Clinical Investigation, Abigael Cheruiyot, PhD, of the Schaffer Lab, led the research that uncovered a translational regulatory circuit within pancreatic beta cells that plays a vital … Continue reading “Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion”

The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans

Aging is a natural process, yet it can be accelerated or delayed by internal and external factors. In particular, CREB-regulated transcriptional coactivators (CRTCs) have emerged as novel modulators of aging … Continue reading “The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans”

Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion

In a paper published in JCI Insight, titled, “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”, a team of researchers from the Hotamışlıgil … Continue reading “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans

In a recent paper published in PLoS Genetics, Dr. Mair and his team led by Hannah Smith, demonstrated that selectively inhibiting mechanistic target of rapamycin complex 1 (mTORC1) in neurons … Continue reading “Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans”

Mitochondrial morphology controls fatty acid utilization by changing CPT1sensitivity to malonyl-CoA

In a paper published in the EMBO Journal in February, the Danial (Molecular Metabolism/ Dana Farber Cancer Institute) and Shirihai (UCLA) labs reported that fatty acid utilization is selectively coupled … Continue reading “Mitochondrial morphology controls fatty acid utilization by changing CPT1sensitivity to malonyl-CoA”

mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species

In a recent paper published in Nature Metabolism mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species, Department of Molecular Metabolism postdoctoral fellow Aaron Hosios and other colleagues in … Continue reading “mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species”

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

In a paper published in iScience, Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex, from the Laboratory of Professor Brendan Manning,  MollyMcNamara Goodrich … Continue reading “Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex”

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

In a paper published in Cell Reports, Schrötter and colleagues describe a mouse knockout model of TBC1D7, a core component of the complex disrupted in a genetic tumor and neurological … Continue reading “The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth”

Professor Marianne Wessling-Resnick Distinguished Lecture

Sponsored by the Department of Molecular Metabolism Harvard T.H. Chan School of Public Health May 3 @ 12 PM EST The Inaugural Professor Marianne Wessling-Resnick Distinguished Lecturer Peter Tontonoz, MD, PhD … Continue reading “Professor Marianne Wessling-Resnick Distinguished Lecture”