June 2017 Nanolecture Series Event

Grouping of nanomaterials: The value of extrinsic properties, of lifecycle transformation and release behavior

Wendel Wohlleben, Ph.D.
Senior Scientist
Department of Material Physics,
Department of Experimental Toxicology and Ecology At BASF
Ludwigshafen, Germany
June 28th, 2017
12:30-1:30 pm
665 Huntington Ave,
Bldg. 1, Room 1302,
Boston, MA, 02115

Abstract: Similarity to known benchmark materials can be a powerful tool to reduce the uncertainty related to the risks of innovative (nano)materials, and to revisit the safety of established materials such as fillers and pigments that are produced in Megaton quantities in many different (nano)forms. In the frame of ECETOC and collaborative projects with academics and regulators, we advanced the implementation of a grouping framework that proceeds in three tiers: (1) The ECHA and EPA concepts of „nanoforms“ and „discrete forms“, respectively, group materials by similarity of intrinsic physicochemical properties such as composition, shape, size, surface chemistry. (2) This talk will go further towards refined grouping and substantiation of read-across that relies on extrinsic properties, reflecting the lifecycle of nano-enabled products and their bio-phys-chem interactions. (3) In vivo studies remain the last resort and currently serve to calibrate the grouping and read-across hypothesis. Families of pigments & silicates can now be grouped and ranked against benchmark materials by measured descriptors of releases, mobility, reactivity and transformation/dissolution.

Biographical Sketch: Wendel Wohlleben is Senior Scientist for characterization of nanomaterials at BASF, Dept. of Material Physics, second affiliation with Dept. of Experimental Toxicology and Ecology. Conducts or leads research projects on advanced materials development and on the safety of nanomaterials, specifically SUN FP7 (Lifecycle testing of nanomaterials), NanoDefine FP7 (identification and characterization of nanomaterials), nanoGRAVUR BMBF (grouping of nanomaterials), NanoRelease (Release testing). More than 100 papers and patents, h-index =37. Additional responsibilities for chance finding on novel advanced materials and on monitoring and implementation of novel analytical methods at BASF. Wendel studied physics (minor: chemistry) at the University Heidelberg and at the Ecole Normale Supérieure in Paris. PhD in 2003 from University Munich with a biophysical thesis on energy harvesting in photosynthesis, performed at the Max-Planck-Institute for Quantum Optics. Post-doc at Physical Chemistry, University Marburg. Visiting scientist relations at Dept. of Materials and Interfaces, Weizmann Institute, Rehovot and at Harvard TH Chan School of Public Health, Boston.