Joel Cohen

Short Bio

After receiving a BS degree in Public Health and Environmental Studies from Tufts University, Joel enrolled at HSPH as a doctoral candidate in Environmental Health in the Molecular and Integrated Physiological Sciences program.  He joined the Laboratory for Environmental Health Nanosciences in 2010 under Center Director Dr. Philip Demokritou, where he received training in state-of-the art nanomaterial characterization techniques in both dry powder form and in liquid suspension, as well in vitro techniques for measuring nano-cellular interactions and toxicity.

Research Interests

Joel’s research interests include particle-cell interactions at the nano-bio interface using various in vitro models for measuring nanomaterial toxicity, cellular uptake, and nanomaterial translocation across cellular monolayers.  Additionally, he has developed a methodology to improve in vitro dosimetry via careful characterization of ENM interactions in liquid suspension, and modeling the subsequent effects on particle transport and delivery to cells in culture.  Joel’s research has relied on electron microscopy, dynamic light scattering, analytical ultracentrifugation, and various in vitro cellular models of nano-bio interactions.

Center Involvement

  1. Interactions of Engineered Nanomaterials in Physiological Fluids: Implications for In Vitro Nanotoxicology and Dosimetry
  2. Safe by design: Demonstrating the efficiency of a safer formulation concept for flame-generated engineered nanomaterials (ENMs)
  3. Acute inhalation study of realistic nano scale CeO2 using the Harvard VENGES toxicological platform
  4. Tracking Translocation of Industrially Relevant Engineered Nanomaterials (ENMs) Across Alveolar Epithelial Monolayers In Vitro

Selected Publications

  1. Interactions of Engineered Nanomaterials in Physiological Media and Implications for In Vitro Dosimetry. J. Cohen, G. Deloid, G. Pyrgiotakis and P. Demokritou, Nanotoxicology – (2012) – doi: 10.3109/17435390.2012.666576 [pdf]
  2. Safer Formulation Concept for Flame-Generated Engineered Nanomaterials. S. Gass, J. M. Cohen, G Pyrgiotakis, G. A. Sotiriou, R. Derk, L. Rojanasakul, S. E. Pratsinis, P. Demokritou, ACS Environmental Science and Technology. – doi:10.1021/sc300152f [pdf]
  3. An in vivo and in vitro toxicological characterization of realistic nanoscale CeO2 inhalation exposures. P. Demokritou , S. Gass, G. Pyrgiotakis, J. M. Cohen, W. Goldsmith, W. McKinney, D. Frazer, J. Y Ma, D. Schwegler-Berry, J.D. Brain, V. Castranova, Nanotoxicology – doi:10.3109/17435390.2012.666576 [pdf]