|Chris Carman earned a Ph.D. in Molecular Pharmacology and Structural Biology from Thomas Jefferson University, Philadelphia, PA in 1999. He then performed a post-doctoral study at Harvard Medical School with Timothy A. Springer. In 2006 Chris became Assistant Professor of Medicine in the Division of Molecular and Vascular Medicine at Beth Israel Deaconess Medical Center and a founding member of the Center for Vascular Biology Research. In 2017, Chris moved to the Harvard T.H. Chan School of Public Health.
Chris’s research interests broadly include the vascular and cell biology of inflammation and the role of tissue microenvironment in the control of innate and adaptive immune responses. One particular area of focus is on leukocyte-endothelial interactions. The vascular endothelium is the monolayer of cells that lines the cardiovascular system and serves as the critical barrier between the tissues and the blood. In this way, the endothelium plays critical roles in directing the trafficking patterns, as well as activation states of leukocytes. Our work makes extensive use of advanced fluorescence imaging, electron microscopy and biomechanical approaches to understand the fundamental basis and consequences of leukocyte-endothelial interactions and how they may become perturbed during inflammatory and immune-related diseases.
More recently Chris has developed interests in understanding how both immune and stromal cells perceive and respond to various types of ‘danger signals’ (e.g., pathogens, host cell damage and environmental exposure to nanomaterials) to promote local pathology as well as systemic cardiovascular disease.
Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science. 2003, 301:1720-5. Co-First Author
Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH, Van Etten RA. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defense and tumor suppression. Nature. 2003, 424:561-5.
Carman CV, Springer TA. A Transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol. 2004, 167:377-88.
Carman CV, Sage PT, Sciuto TE, de la Fuete MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA. Trans-cellular diapedesis is initiated by leukocyte podosomes. Immunity. 2007, 26:784-97.
Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 2008, 319:627-30.
Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW. Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3epsilon Cytoplasmic Tyrosine-Based Motif. Cell. 2008, 135:702-13.
Sage PT, Varghese L., Martinelli R., Sciuto T., Kamei M, Dvorak A, Springer TA, Sharpe A, Carman CV*. Antigen Recognition is Facilitated by Invadosome-Like Protrusions Formed by Memory/Effector T cells. J Immunol. 2012, 188: 3686-99.
Teo, G, Ankrum JA, Martinelli RM, Boetto SE, Simms K, Sciuto TE, Dvorak AM, Karp JM, Carman CV*. Mesenchymal Stem Cells Transmigrate Between and Directly Through Tumor Necrosis Factor-α-Activated Endothelial Cells Via Both Leukocyte-Like and Novel Mechanisms. Stem Cells. 2012, 30: 2472-86.
Zonneveld R, Martinelli R, Kuijpers TW, Plötz FW, Carman CV. The role of adhesion molecules in sepsis and the potential pathophysiological discrepancy in neonates, children and adults. Crit Care. 2014; 18: 204
Carman CV, Martinelli R. T cell-Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity. Frontiers in Immunology 2015, 6:603. *Co-corresponding authors.
Chris has >70 number of publications in peer-reviewed journals in various research fields. Google Scholar Link: https://scholar.google.com/citations?user=gPNm8rEAAAAJ&hl=en