Harvard T.H. Chan School of Public Health partners with the National Institutes of Health and Apple for Women’s Health Study

Multiple exposure of diverse women walking

Groundbreaking study will collect and analyze data on menstrual and gynecological health to improve women’s health across the lifespan

For immediate release: September 10, 2019

Boston, MA – Harvard T.H. Chan School of Public Health, Apple, and the National Institutes of Health announced today a collaboration for the Apple Women’s Health Study, a large-scale longitudinal study led by a team of researchers at the Harvard Chan School that will leverage participants’ voluntary use of a smartphone research app to advance our understanding of menstrual and gynecological health.

By making use of information and study activities from personal devices, the first-of-its-kind study has the potential to become the largest and longest-running longitudinal study of women’s health. The study, focused on menstrual cycles and gynecological conditions, will inform screening and risk assessment of conditions including polycystic ovary syndrome (PCOS), infertility, osteoporosis, breast cancer, pregnancy complications, and menopausal transition.

“Women make up half of the world’s population, yet even today there has been limited investment in studying their unique health needs,” said Michelle A. Williams, a reproductive epidemiologist and dean of the faculty at the Harvard Chan School. “This study, unprecedented in scope, will greatly advance our understanding of the biological and social determinants of women’s health, and lead to better health outcomes.”

In recent years, researchers have acknowledged the need to reevaluate the relationship of menstruation to overall health outcomes in women. Treating the menstrual cycle as a vital sign—comparable to blood pressure, temperature, pulse rate, and respiration rate—could lead to the earlier detection of many health conditions, both gynecological and systemic, as well as a better understanding of women’s reproductive health and health needs across the lifespan. “This study represents a tremendous opportunity to bridge disciplinary domains across reproductive endocrinology, clinical epidemiology, and public health data science at Harvard,” said Michael Grusby, acting dean for academic affairs at the Harvard Chan School. “Faculty and staff from across the university have come together to give their strongest possible support to the study’s principal investigators.”

Dean Williams, Angelopoulos Professor in Public Health and International Development, will lead the study as a principal investigator, along with Harvard Chan School co-principal investigators Russ Hauser, Frederick Lee Hisaw Professor of Reproductive Physiology and chair of the Department of Environmental Health, and Brent Coull, professor of biostatistics and associate chair of the Department of Biostatistics. The other Harvard Chan School researchers are Shruthi Mahalingaiah, assistant professor of environmental reproductive and women’s health, and Jukka-Pekka Onnela, associate professor of biostatistics and director of the Master’s Program in Health Data Science. Members of the Harvard Chan School and Apple teams will be joined by colleagues from the National Institute of Environmental Health Sciences.

The Apple Women’s Health Study will be part of Apple’s Research app available later this year, and is facilitated by a research agreement between Apple and Harvard’s Office of Technology Development. “This study enables Harvard Chan researchers to vastly extend the reach of conventional data collection and analysis,” said Isaac Kohlberg, Harvard’s Chief Technology Development Officer and Senior Associate Provost. “This study is a potent example of how thoughtful collaboration between academia and industry can innovatively advance the practice of research in public health.”

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Chris Sweeney


Harvard T.H. Chan School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people’s lives—not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at Harvard Chan School teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America’s oldest professional training program in public health.