Faculty Projects

Addressing maternal infection combined with nutrition support to reduce fetal growth retardation and preterm birth and improve linear growth in Africa (10/28/17-10/28/18)

An estimated 20 million babies are born <2500g (low birth weight, LBW) annually. The World Health Organization (WHO) Global Nutrition Target #3 is to reduce the prevalence of LBW babies 30% by the year 2025 to achieve the Sustainable Development Goals.   Nutritional interventions alone may not be sufficient to achieve this goal.  Maternal infections and … Continue reading “Addressing maternal infection combined with nutrition support to reduce fetal growth retardation and preterm birth and improve linear growth in Africa (10/28/17-10/28/18)”

Testing the efficacy of a designed nutritious food supplement for pregnancy on small for gestational age, preterm birth and low birthweight in Burkina Faso (3/10/18-2/29/19)

This formative study aims to a) identify preferred product types for the provision of fortified balanced energy-protein (BEP) supplements and 2) assess the 8-week acceptability and at-home consumption of up to 2 supplements among pregnant women (PW) in Burkina Faso. As recommended in the 2016 WHO antenatal care guidelines, pregnant women in undernourished populations should … Continue reading “Testing the efficacy of a designed nutritious food supplement for pregnancy on small for gestational age, preterm birth and low birthweight in Burkina Faso (3/10/18-2/29/19)”

Assessing the risk of hospital-acquired infection and multi-drug resistance among hospitalized severe acutely malnourished children (6/01/15-12/31/19)

The goal of this descriptive study is to collect information on the risk of health care acquired infection in MSF-supported inpatient nutritional treatment centers.  Information on key clinical indicators will be collected regularly from the time of admission to discharge.  As part of active surveillance for bacterial transmission and colonization, including multi-drug resistant organisms, all … Continue reading “Assessing the risk of hospital-acquired infection and multi-drug resistance among hospitalized severe acutely malnourished children (6/01/15-12/31/19)”

Predictors and consequences of gestational weight gain in low- and middle-income countries (LMICs) settings (2/20/2019 – 07/31/2022)

The project will examine the impact of gestational weight gain (GWG) as a determinant of pregnancy outcomes in the context of LMICs using pregnancy cohorts in the GHAP datasets and others. Secondary data analyses will be undertaken to (i) identify geographic patterns in the distribution of GWG, (ii) identify risk factors inadequate GWG, (iii) evaluate … Continue reading “Predictors and consequences of gestational weight gain in low- and middle-income countries (LMICs) settings (2/20/2019 – 07/31/2022)”

Demonstrating non-inferiority of a lower dose (500mg) calcium supplementation during pregnancy for reducing preeclampsia (PE) and neonatal outcomes (10/15/2017-8/31/2022)

The objective of this study is to generate causal evidence for decision-making on the potential non-inferiority of a lower dose of calcium in preventing preeclampsia and preterm birth and to understand the acceptability, uptake, and adherence to the WHO recommended 1500 mg calcium supplementation among pregnant women in Tanzania and India. We will conduct two, … Continue reading “Demonstrating non-inferiority of a lower dose (500mg) calcium supplementation during pregnancy for reducing preeclampsia (PE) and neonatal outcomes (10/15/2017-8/31/2022)”

Formative study to assess the acceptability and utilization of preferred fortified balanced energy-protein supplements in Southern Nepal (10/01/17-12/31/20)

This formative study aims to a) identify preferred product types for the provision of fortified balanced energy-protein (BEP) supplements and 2) assess the 8-week acceptability and at-home consumption of up to 2 supplements among pregnant women (PW) in southern Nepal. As recommended in the 2016 WHO antenatal care guidelines, pregnant women in undernourished populations should … Continue reading “Formative study to assess the acceptability and utilization of preferred fortified balanced energy-protein supplements in Southern Nepal (10/01/17-12/31/20)”

Operational experience on the use of mid upper arm circumference for the admission, monitoring and discharge of children under treatment for uncomplicated severe acute malnutrition in Madaoua, Niger (7/01/17-7/31/20)

The non-randomized intervention study will aims to provide evidence for the simplification of international nutritional protocols using mid upper arm circumference (MUAC) vs. the standard protocol using both weight-for-height and MUAC for the admission, monitoring and discharge of children with uncomplicated severe acute malnutrition. A total of 6,100 infants aged 6-59 months will be included … Continue reading “Operational experience on the use of mid upper arm circumference for the admission, monitoring and discharge of children under treatment for uncomplicated severe acute malnutrition in Madaoua, Niger (7/01/17-7/31/20)”

Identifying genetic determinants of Rotavirus Vaccine Failure in Malawian Children (1/01/19-12/31/23)

Rotavirus is the leading cause of severe childhood gastroenteritis, resulting in over 215,000 deaths per year. The recently introduced live, oral rotavirus vaccine (RVV) demonstrated 90-95% protection in Europe and the US, but is less than 50% in low income countries, where the disease burden is highest. The biological basis of rotavirus vaccine failure remains … Continue reading “Identifying genetic determinants of Rotavirus Vaccine Failure in Malawian Children (1/01/19-12/31/23)”

Optimizing place of treatment and antibiotic regimens for young infants presenting with signs of possible serious bacterial infection

This seven site randomized trial (Tanzania, Ethiopia, Nigeria, India, Pakistan, Bangladesh) coordinated by WHO will consist of two trials and an observational cohort. The first trial will examine the effect of hospital or outpatient treatment on mortality of young infants (1-59 days of age) with low-risk signs of clinical severe infection (CSI). The second trial … Continue reading “Optimizing place of treatment and antibiotic regimens for young infants presenting with signs of possible serious bacterial infection”

Optimizing Adherence to Multiple Micronutrient Supplementation in Pregnancy

The main purpose of the project is to assess innovations to packaging and counselling of maternal multivitamin supplementation in pregnancy to improve coverage and adherence to provide greater population-level benefits. The project will be implemented with Myanmar in collaboration with the Myanmar Ministry of Health and other MMS demonstration projects occurring in Indonesia and Bangladesh. … Continue reading “Optimizing Adherence to Multiple Micronutrient Supplementation in Pregnancy”