PG_Nov2015

Philippe Grandjean

Adjunct Professor of Environmental Health

401 Park Drive
Landmark Center Room 3-110 East
Boston, Massachusetts 02215
Phone: 617.384.8907

Research

Philippe Grandjean was born in Denmark in 1950. He graduated with his MD from the University of Copenhagen at age 23, and six years later he defended his doctoral thesis on the ‘Widening perspectives of lead toxicity’. He became Professor of Environmental Medicine at the University of Southern Denmark in 1982. A Fulbright Senior Scholarship award brought him to Mt.Sinai Hospital in New York, and he later served as Adjunct Professor of Neurology and Environmental Health at Boston University. In 2003, he became Adjunct Professor of Environmental Health at Harvard University. In 2004, he received an unusual recognition – the Mercury Madness Award for excellence in science in the public interest, from eight US environmental organizations. He has also received the Science Communication Award from the University of Southern Denmark, and in 2015, he received the Bernardino Ramazzini Award for “his long career conducting and promoting environmental health research, especially his groundbreaking work on the effects of methylmercury and other environmental toxins affecting children and for his tireless advocacy of the need to protect future generations from the devastating effects of neuro- and developmental toxins.” He lives in Copenhagen, Denmark and in Cambridge, MA, and travels widely to study environmental problems and to examine children whose lives have been affected by pollution, more specifically, the delayed effects of developmental exposure to environmental chemicals.

His most recent projects examine brain development and immune functions in regard to exposures to environmental pollutants, such as perfluorinated compounds and mercury. The results have inspired downward revisions of methylmercury exposure limits internationally and, most recent, the UN’s Minamata Convention. Other recent studies have targeted age-related functional deficits and degenerative diseases, such as Parkinson’s disease, cardiovascular disease, and type 2 diabetes in regard to life-time exposure to methylmercury, arsenic, persistent lipophilic contaminants, and perfluorinated compounds. Other efforts relate to biomarker development and validation, endocrine disruption caused by organochlorine substances. adverse effects of fluoride exposure, and the neurotoxicity of lead. Dr. Grandjean has also published on research ethics, genetic susceptibility, the setting of exposure limits, and the impact of the precautionary principle on prevention and research.

Recent News

New consensus document: Consensus on early origins (2015)

New Web Site: Chemical Brain Drain

New video: Chemical Brain Drain

New Book: Only One Chance

Publications

(Selected articles from 2012-2015)

Grandjean P. Toxicology research for precautionary decision-making and the role of Human & Experimental Toxicology. Hum Exp Toxicol 2015; 34: 1231-7.

Grandjean P, Clapp R. Perfluorinated alkyl substances: emergence of insights into health risks. New Solutions 2015; 25: 147-63.

Jensen TK, Andersen LB, Kyhl HB, Nielsen F, Christensen HT, Grandjean P. Association between perfluorinated compounds and miscarriage in a case-control study of Danish pregnant women. PLoS One 2015; 10: e0123496.

Mogensen UB, Grandjean P, Nielsen F, Weihe P, Budtz-Jørgensen E. Breastfeeding as an exposure pathway for perfluorinated alkylates. Environ Sci Technol 2015; 49: 10466-73.

Bellanger M, Demeneix B, Grandjean P, Zoeller RT, Trasande L. Neurobehavioral deficits, diseases and associated costs of exposure to endocrine disrupting chemicals in the European Union. J Clin Endocrinol Metab 2015; 100: 1256-66.

Grandjean P, Landrigan PJ. Neurobehavioural effects of developmental toxicity. Lancet Neurol 2014; 13: 330-8.

Audouze K, Brunak S, Grandjean P. Computational approach to chemical etiologies of diabetes. Sci Comm 2013; 3: 2712.

Julvez J, Davey-Smith G, Golding J, Ring S, St. Pourcain B, Gonzalez JR, Grandjean P. Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years. Epidemiology 2013; 24: 643-50.

Grandjean P, Ozonoff D. Transparency and translation of science in a modern world. Environ Health 2013; 12: 70.

Balbus JM, Barouki R, Birnbaum LS, Etzel RA, Gluckman PD, Grandjean P, Hancock C, Hanson MA, Heindel JJ, Hoffman K, Jensen GK, Keeling A, Neira M, Rabadán-Diehl C, Ralston J, Tang KC. Early-life prevention of non-communicable diseases (Comment). Lancet 2013; 381: 3-4.

Budtz-Jørgensen E, Bellinger D, Lanphear B, Grandjean P, International Pooled Lead Study Investigators. An international pooled analysis for obtaining a Benchmark dose for environmental lead exposure in children. Risk Anal 2013; 33: 450-61.

Grandjean P, Andersen EW, Budtz-Jørgensen E, Nielsen F, Mølbak K, Weihe P, Heilmann C. Decreased serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA 2012; 307: 391-7.

Wohlfahrt-Veje C, Andersen HR, Jensen TK, Grandjean P, Skakkebaek NE, Main KM. Smaller genitals at school age in boys whose mothers were exposed to non-persistent pesticides in early pregnancy. Int J Androl 2012; 35: 265-72.

Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: A systematic review and meta-analysis. Environ Health Perspect 2012; 120: 1362-8.