Warehouse Work, Health, and Well-Being is a large-scale, randomized controlled trial to test a novel participatory workplace intervention—“Health and Well-being Committees” (HaWCs)—to improve worker voice and well-being among hourly associates across multiple sites in one firm. This study focuses on workers in fulfillment centers in the e-commerce segment of the warehousing and storage industry—a growing and important industry. Warehouse workers face a double burden of physically taxing and high-strain jobs that negatively impact mental and physical health, including injury-related disability. Because fulfillment center workers earn low wages and are disproportionately Black and Latinx, this study aims to modify conditions of work to promote the health of workers who are often subject to systemic health inequities. This project is a collaboration with the Center for Work, Health, and Well-Being at the Harvard T.H. Chan School of Public Health.