THURSDAY, NOVEMBER 20, 2014
8:30-9:00am Registration & Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda
9:00 Opening Remarks
SESSION I : High-Throughput Strategies to Understand Non-coding Allelic Functions
9:00-9:45
Peter Sorger | KEYNOTE SPEAKER
Harvard Medical School
Talk title available soon
9:45-9:50 Questions and Discussion
9:50-10:15
Kevin White
University of Chicago
Widespread Genetic Epistasis Among Cancer Genes
10:15-10:20 Questions and Discussion
10:20-10:30
Abstract Winner Platform Talk
Amnon Koren
Harvard Medical School
Genetic variation in human DNA replication timing
10:30-10:35 Questions and Discussion
10:35-11:00 BREAK
11:00-11:25
William Fairbrother
Brown University
Screening Variants for Defects in Splicing
11:25-11:30 Questions and Discussion
11:30-11:55
Tuuli Lappalainen
Columbia University
Interpreting Functional Variation in Human Genomes by Transcriptome Sequencing
11:55-12:00 Questions and Discussion
12:00-1:15 LUNCH
SESSION II : Integrative Approaches to Interpret the Function of Non-coding Alleles
1:15-2:00
George Church | KEYNOTE SPEAKER
Harvard Medical School
Talk title available soon
2:00-2:05 Questions and Discussion
2:05-2:30
Karen Mohlke
University of North Carolina at Chapel Hill
Regulatory variants at GWAS loci for complex metabolic traits
2:30-2:35 Questions and Discussion
2:35-3:00
Alkes Price
Harvard School of Public Health
Partitioning Heritability Across Functional Categories
3:00-3:05 Questions and Discussion
3:05-3:30 BREAK
3:30-3:40
Abstract Winner Platform Talk
Hilary Finucane
Massachusetts Institute of Technology
Partitioning heritability by functional category using summary statistics
3:40-3:45 Questions and Discussion
3:45-4:45
PANEL DISCUSSION
Interpreting the Function of Disease Alleles
Panelists:
Daniel MacArthur, Harvard Medical School
Soumya Raychaudhuri, Harvard Medical School
Barbara Stranger, University of Chicago
Shamil Sunyaev, Harvard Medical School
4:45-6:30 Poster Session and Reception | 2nd floor lounge
FRIDAY, NOVEMBER 21, 2014
8:30-9:00am Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda
SESSION III : Interpreting the function of coding alleles
9:00-9:45
Nazneen Rahman | KEYNOTE SPEAKER
The Institute of Cancer Research
Insights into the complexity of allelic function from clinical sequencing
9:45-9:50 Questions and Discussion
9:50-10:15
Mark Daly
Massachusetts General Hospital
Prioritizing and Interpreting Rare Variation & Exome Sequencing
10:15-10:20 Questions and Discussion
10:20-10:45
Jay Shendure
University of Washington
New Computational and Experimental Approaches to Variant Interpretation
10:45-10:50 Questions and Discussion
10:50-11:00
Abstract Winner Platform Talk
Luis Barrera
Harvard Medical School
Disease-associated mutations and coding variants in human transcription factors
11:00-11:05 Questions and Discussion
11:05-11:30
Nicholas Katsanis
Duke University
Modeling the Morbid Human Genome
