THURSDAY, NOVEMBER 5, 2015
8:30-9:00am Registration & Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda
9:00 Opening Remarks
SESSION I : Emerging Technologies for Genome-scale Single-cell Analysis
9:00-9:45
George Church | KEYNOTE SPEAKER
Harvard Medical School and MIT
In situ Omics & the BRAIN initiative
9:45-9:50 Questions and Discussion
9:50-10:15
James Eberwine
University of Pennsylvania Perelman School of Medicine
Single Cell/Subcellular Variability and Theories of Cellular Phenotype
10:15-10:20 Questions and Discussion
10:20-10:30
Stephanie Hicks – Abstract Winner
Dana-Farber Cancer Institute / Harvard Chan School
On the widespread and critical impact of systematic bias and batch effects in single-cell RNA-Seq data
10:30-10:35 Questions and Discussion
10:35-11:00 BREAK
11:00-11:25
William Greenleaf
Stanford School of Medicine
Single-cell chromatin accessibility reveals principles of regulatory variation
11:25-11:30 Questions and Discussion
11:30-11:55
Kun Zhang
University of California, San Diego
Sequencing and Mapping of RNA Molecules in Human Adult Brain
11:55-12:00 Questions and Discussion
12:00-1:00 LUNCH
1:00 – 1:15
Special Talk | Bob Jones, Fluidigm
New Tools for Single-Cell Biology
SESSION II : Computational Methods for Analyzing Single-cell Genomic Data
1:15-2:00
Michael Elowitz | KEYNOTE SPEAKER
California Institute of Technology
An operational perspective on mammalian signaling and epigenetic memory circuits using synthetic biology and single-cell dynamics
2:00-2:05 Questions and Discussion
2:05-2:30
Sylvia Plevritis
Stanford School of Medicine
Optimizing Combination Cancer Therapy Based on Single Cell Analysis
2:30-2:35 Questions and Discussion
2:35-3:00
Raphael Gottardo
Fred Hutchinson Cancer Research Center
MAST: A novel statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA-seq data
3:00-3:05 Questions and Discussion
3:05-3:30 BREAK
3:30-3:40
Martin Hemberg – Abstract Winner
Wellcome Trust Sanger Institute
SC3 – Consensus clustering of single-cell RNA-seq data
3:40-3:45 Questions and Discussion
3:45-4:10
John Marioni
European Bioinformatics Institute
Using Single-cell Genomics to Study Early Development
4:10-4:15 Questions and Discussion
4:15-6:15 Poster Session and Reception | 2nd floor lounge
FRIDAY, NOVEMBER 6, 2015
8:30-9:00am Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda
SESSION III : Applications of Single-cell Technologies in Human Health and Diseases
9:00-9:45
Sten Linnarsson | KEYNOTE SPEAKER
Karolinska Institutet
Molecular Anatomy of the Mouse Brain by Single-cell RNA-seq
9:45-9:50 Questions and Discussion
9:50-10:15
Galit Lahav
Harvard Medical School
Connecting protein dynamics with drug resistance in individual cells
10:15-10:20 Questions and Discussion
10:20-10:45
Nicholas Navin
MD Anderson Cancer Center
Investigating Clonal Evolution with Single Cell Genomics
10:45-10:50 Questions and Discussion
10:50-11:00
Michalina Janiszewska – Abstract Winner
Dana-Farber Cancer Institute / Harvard Chan School
The effect of chemotherapy on HER2+ breast cancer heterogeneity measured by STAR-FISH: Detection of PIK3CA mutation and HER2 amplification at single-cell level in situ
11:00-11:05 Questions and Discussion
11:05-11:30
Catherine Wu
Dana-Farber Cancer Institute & Harvard Medical School
Precise dissection of genetic and transcriptional heterogeneity in chronic lymphocytic leukemia by single cell analysis
11:30-11:35 Questions and Discussion
11:35 Closing Remarks
