Thursday, November 3, 2016
8:30-9:00am Registration & Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda
9:00 Opening Remarks
Benjamin Neale, Conference Chair
SESSION I: PATH TO GENOMICS
9:00-9:45
Stacey Gabriel | KEYNOTE SPEAKER
The Broad Institute
A genome every 15 minutes – sequencing genomes at scale
9:45-9:50 Questions and Discussion
9:50-10:15
Steven McCarroll, Harvard Medical School
Complex forms of genome variation in human disease
10:15-10:20 Questions and Discussion
10:20-10:30
Abstract Winner Platform Talk I
Corneliu Bodea, Brigham & Women’s Hospital, Harvard Medical School, Merck
Predicting functional noncoding variation: an unsupervised phenotype-informed approach
10:30-10:35 Questions and Discussion
10:35-11:00 BREAK
11:00-11:25
Iuliana Ionita-Laza, Columbia University
Integrative statistical approaches for functional prediction of genetic variation
11:25-11:30 Questions and Discussion
11:30-11:55
Gonçalo Abecasis, University of Michigan
Sequence and analysis of 10,000 human genomes: computational challenges and opportunities
11:55-12:00 Questions and Discussion
12:00-1:15 LUNCH
SESSION II : SCALING UP PHENOTYPES
1:15-2:00
Nancy Cox | KEYNOTE SPEAKER
Vanderbilt University
Integrating genome and transcriptome for discovery across the medical phenome
2:00-2:05 Questions and Discussion
2:05-2:30
Mark Daly, Massachusetts General Hospital
Beyond GWAS: moving from genetics to therapeutic targets in inflammatory bowel disease
2:30-2:35 Questions and Discussion
2:35-3:00
Issac Kohane, Harvard Medical School, Boston Children’s Hospital
Fake diseases and dangerous phenotypes
3:00-3:05 Questions and Discussion
3:05-3:30 BREAK
3:30-3:40
Abstract Winner Platform Talk II
Andrea Ganna, Massachusetts General Hospital
The impact of ultra-rare disruptive mutations in highly constrained genes on human diseases and quantitative traits
3:40-3:45 Questions and Discussion
3:45-4:10
Tuuli Lappalainen, Columbia University & New York Genome Center
Functional variation in the human genome: lessons from the transcriptome
4:10-4:15 Questions and Discussion
4:15-6:00 Poster Session and Reception | 2nd floor lounge
Friday, November 4, 2016
8:30-9:00am Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda
SESSION III: NEW HORIZONS IN POPULATION GENETICS
9:00-9:45
Jonathan Pritchard | KEYNOTE SPEAKER
Stanford University
Effects of human genetic variation from gene regulation to adaptation
9:45-9:50 Questions and Discussion
9:50-10:15
Joshua Akey, University of Washington
Excavating archaic hominin DNA from the genomes of modern humans
10:15-10:20 Questions and Discussion
10:20-10:45
David Reich, Harvard Medical School
Ancient DNA as a new instrument for studying human biology
10:45-10:50 Questions and Discussion
10:50-11:00
Abstract Winner Platform Talk
III
Vagheesh Narasimhan, Wellcome Trust Sanger Institute
A direct multi-generational estimate of the human mutation rate from autozygous segments seen in thousands of parentally related individuals
11:00-11:05 Questions and Discussion
11:05-11:30
Sarah Tishkoff, University of Pennsylvania
African evolutionary genomics: implications for human evolution and disease
11:30-11:35 Questions and Discussion
11:35 Closing Remarks
Xihong Lin, PQG Coordinating Director
