Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect.
Hosios AM, Manning BD.
Cancer Res. 2021 10 01. 81(19):4896-4898. PMID: 34598998
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Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
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Elife. 2021 03 01. 10. PMID: 33646118
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.
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Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.
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Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate.
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Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.
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Lysosomal catch-and-release controls mTORC1.
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Aspartate is an endogenous metabolic limitation for tumour growth.
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