Aaron M Hosios

Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells.

Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G.

FEBS J. 2021 Apr 03. PMID: 33811729

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.

Torrence ME, MacArthur MR, Hosios AM, Valvezan AJ, Asara JM, Mitchell JR, Manning BD.

Elife. 2021 Mar 01. 10. PMID: 33646118

Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.

Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S.

Sci Rep. 2020 Jul 21. 10(1):12054. PMID: 32694612

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.

Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MG.

Nat Commun. 2019 12 06. 10(1):5604. PMID: 31811141

Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.

Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Vander Heiden MG.

FEBS Lett. 2020 02. 594(4):646-664. PMID: 31642061

Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate.

Dexter JP, Ward PS, Dasgupta T, Hosios AM, Gunawardena J, Vander Heiden MG.

J Biol Chem. 2018 12 28. 293(52):20051-20061. PMID: 30381394

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.

Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W.

EMBO J. 2018 11 15. 37(22). PMID: 30348863

Lysosomal catch-and-release controls mTORC1.

Hosios AM, Manning BD.

Nat Cell Biol. 2018 Sep. 20(9):996-997. PMID: 30154562

Aspartate is an endogenous metabolic limitation for tumour growth.

Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG.

Nat Cell Biol. 2018 07. 20(7):782-788. PMID: 29941931

The redox requirements of proliferating mammalian cells.

Hosios AM, Vander Heiden MG.

J Biol Chem. 2018 05 18. 293(20):7490-7498. PMID: 29339555