Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect.
Hosios AM, Manning BD.
Cancer Res. 2021 Oct 01. 81(19):4896-4898. PMID: 34598998
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Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G.
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
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Elife. 2021 Mar 01. 10. PMID: 33646118
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.
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Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.
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Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.
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Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate.
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Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.
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Lysosomal catch-and-release controls mTORC1.
Hosios AM, Manning BD.
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Aspartate is an endogenous metabolic limitation for tumour growth.
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