Alexander Gusev

Immunotherapy-mediated thyroid dysfunction: genetic risk and impact on outcomes with PD-1 blockade in non-small cell lung cancer.

Luo J, Martucci VL, Quandt Z, Groha S, Murray MH, Lovly CM, Rizvi H, Egger JV, Plodkowski AJ, Abu-Akeel M, Schulze I, Merghoub T, Cardenas E, Huntsman S, Li M, Hu D, Gubens MA, Gusev A, Aldrich MC, Hellmann MD, Ziv E.

Clin Cancer Res. 2021 Jul 08. PMID: 34244291

Gene fusions create partner and collateral dependencies essential to cancer cell survival.

Gillani R, Seong BKA, Crowdis J, Conway JR, Dharia NV, Alimohamed S, Haas BJ, Han K, Park J, Dietlein F, He MX, Imamovic A, Ma C, Bassik MC, Boehm JS, Vazquez F, Gusev A, Liu D, Janeway KA, McFarland JM, Stegmaier K, Van Allen EM.

Cancer Res. 2021 Jun 07. PMID: 34099491

Clinical Inflection Point Detection on the Basis of EHR Data to Identify Clinical Trial-Ready Patients With Cancer.

Kehl KL, Groha S, Lepisto EM, Elmarakeby H, Lindsay J, Gusev A, Van Allen EM, Hassett MJ, Schrag D.

JCO Clin Cancer Inform. 2021 06. 5:622-630. PMID: 34097438

CDKN2A Alterations and Response to Immunotherapy in Solid Tumors.

Adib E, Nassar AH, Akl EW, Abou Alaiwi S, Nuzzo PV, Mouhieddine TH, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Shukla SA, Gusev A, Braun DA, Choueiri TK, Kwiatkowski DJ.

Clin Cancer Res. 2021 Jul 15. 27(14):4025-4035. PMID: 34074656

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies.

Feng H, Mancuso N, Gusev A, Majumdar A, Major M, Pasaniuc B, Kraft P.

PLoS Genet. 2021 Apr. 17(4):e1008973. PMID: 33831007

Trans-ethnic variation in germline variants of patients with renal cell carcinoma.

Abou Alaiwi S, Nassar AH, Adib E, Groha SM, Akl EW, McGregor BA, Esplin ED, Yang S, Hatchell K, Fusaro V, Nielsen S, Kwiatkowski DJ, Sonpavde GP, Pomerantz M, Garber JE, Freedman ML, Rana HQ, Gusev A, Choueiri TK.

Cell Rep. 2021 Mar 30. 34(13):108926. PMID: 33789101

Prediction of severe immune-related adverse events requiring hospital admission in patients on immune checkpoint inhibitors: study of a population level insurance claims database from the USA.

Kalinich M, Murphy W, Wongvibulsin S, Pahalyants V, Yu KH, Lu C, Wang F, Zubiri L, Naranbhai V, Gusev A, Kwatra SG, Reynolds KL, Semenov YR.

J Immunother Cancer. 2021 Mar. 9(3). PMID: 33789879

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.

Carrot-Zhang J, Soca-Chafre G, Patterson N, Thorner AR, Nag A, Watson J, Genovese G, Rodriguez J, Gelbard MK, Corrales-Rodriguez L, Mitsuishi Y, Ha G, Campbell JD, Oxnard GR, Arrieta O, Cardona AF, Gusev A, Meyerson M.

Cancer Discov. 2021 Mar. 11(3):591-598. PMID: 33268447

Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations.

Nait Saada J, Kalantzis G, Shyr D, Cooper F, Robinson M, Gusev A, Palamara PF.

Nat Commun. 2020 11 30. 11(1):6130. PMID: 33257650

Optimized homomorphic encryption solution for secure genome-wide association studies.

Blatt M, Gusev A, Polyakov Y, Rohloff K, Vaikuntanathan V.

BMC Med Genomics. 2020 07 21. 13(Suppl 7):83. PMID: 32693805