Alexander Gusev

Elucidating analytic bias due to informative cohort entry in cancer clinico-genomic datasets.

Kehl KL, Uno H, Gusev A, Groha S, Brown S, Lavery JA, Schrag D, Panageas KS.

Cancer Epidemiol Biomarkers Prev. 2023 Jan 09. PMID: 36626408

Germline variants associated with toxicity to immune checkpoint blockade.

Groha S, Alaiwi SA, Xu W, Naranbhai V, Nassar AH, Bakouny Z, El Zarif T, Saliby RM, Wan G, Rajeh A, Adib E, Nuzzo PV, Schmidt AL, Labaki C, Ricciuti B, Alessi JV, Braun DA, Shukla SA, Keenan TE, Van Allen E, Awad MM, Manos M, Rahma O, Zubiri L, Villani AC, Fairfax B, Hammer C, Khan Z, Reynolds K, Semenov Y, Schrag D, Kehl KL, Freedman ML, Choueiri TK, Gusev A.

Nat Med. 2022 12. 28(12):2584-2591. PMID: 36526723

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma.

Taylor CA, Watson RA, Tong O, Ye W, Nassiri I, Gilchrist JJ, de Los Aires AV, Sharma PK, Koturan S, Cooper RA, Woodcock VK, Jungkurth E, Shine B, Coupe N, Payne MJ, Church DN, Naranbhai V, Groha S, Emery P, Mankia K, Freedman ML, Choueiri TK, Middleton MR, Gusev A, Fairfax BP.

Nat Med. 2022 12. 28(12):2592-2600. PMID: 36526722

Prediction of early-stage melanoma recurrence using clinical and histopathologic features.

Wan G, Nguyen N, Liu F, DeSimone MS, Leung BW, Rajeh A, Collier MR, Choi MS, Amadife M, Tang K, Zhang S, Phillipps JS, Jairath R, Alexander NA, Hua Y, Jiao M, Chen W, Ho D, Duey S, Németh IB, Marko-Varga G, Valdés JG, Liu D, Boland GM, Gusev A, Sorger PK, Yu KH, Semenov YR.

NPJ Precis Oncol. 2022 Oct 31. 6(1):79. PMID: 36316482

The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats.

Munro D, Wang T, Chitre AS, Polesskaya O, Ehsan N, Gao J, Gusev A, Woods LCS, Saba LM, Chen H, Palmer AA, Mohammadi P.

Nucleic Acids Res. 2022 10 28. 50(19):10882-10895. PMID: 36263809

Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors.

Nassar AH, Adib E, Abou Alaiwi S, El Zarif T, Groha S, Akl EW, Nuzzo PV, Mouhieddine TH, Perea-Chamblee T, Taraszka K, El-Khoury H, Labban M, Fong C, Arora KS, Labaki C, Xu W, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Zaitlen N, Schoenfeld AJ, Schultz N, Berger MF, MacConaill LE, Ananda G, Kwiatkowski DJ, Choueiri TK, Schrag D, Carrot-Zhang J, Gusev A.

Cancer Cell. 2022 10 10. 40(10):1161-1172.e5. PMID: 36179682

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci.

Thompson M, Gordon MG, Lu A, Tandon A, Halperin E, Gusev A, Ye CJ, Balliu B, Zaitlen N.

Nat Commun. 2022 09 28. 13(1):5704. PMID: 36171194

Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.

Baca SC, Singler C, Zacharia S, Seo JH, Morova T, Hach F, Ding Y, Schwarz T, Huang CF, Anderson J, Fay AP, Kalita C, Groha S, Pomerantz MM, Wang V, Linder S, Sweeney CJ, Zwart W, Lack NA, Pasaniuc B, Takeda DY, Gusev A, Freedman ML.

Nat Genet. 2022 09. 54(9):1364-1375. PMID: 36071171

The impact of stage-related features in melanoma recurrence prediction: A machine learning approach.

Wan G, Leung B, Nguyen N, DeSimone MS, Liu F, Choi MS, Ho D, Laucks V, Duey S, Sullivan RJ, Boland GM, LeBoeuf NR, Liu D, Gusev A, Kwatra SG, Sorger PK, Yu KH, Semenov YR.

JAAD Int. 2023 Mar. 10:28-30. PMID: 36425793

Pre-Existing Autoimmune Disease and Mortality in Patients Treated with Anti-PD-1 and Anti-PD-L1 Therapy.

Tang K, Tiu BC, Wan G, Zhang S, Nguyen N, Leung B, Gusev A, Reynolds KL, Kwatra SG, Semenov YR.

J Natl Cancer Inst. 2022 08 08. 114(8):1200-1202. PMID: 35188215