Alexander Gusev

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies.

Feng H, Mancuso N, Gusev A, Majumdar A, Major M, Pasaniuc B, Kraft P.

PLoS Genet. 2021 Apr 08. 17(4):e1008973. PMID: 33831007

Trans-ethnic variation in germline variants of patients with renal cell carcinoma.

Abou Alaiwi S, Nassar AH, Adib E, Groha SM, Akl EW, McGregor BA, Esplin ED, Yang S, Hatchell K, Fusaro V, Nielsen S, Kwiatkowski DJ, Sonpavde GP, Pomerantz M, Garber JE, Freedman ML, Rana HQ, Gusev A, Choueiri TK.

Cell Rep. 2021 Mar 30. 34(13):108926. PMID: 33789101

Prediction of severe immune-related adverse events requiring hospital admission in patients on immune checkpoint inhibitors: study of a population level insurance claims database from the USA.

Kalinich M, Murphy W, Wongvibulsin S, Pahalyants V, Yu KH, Lu C, Wang F, Zubiri L, Naranbhai V, Gusev A, Kwatra SG, Reynolds KL, Semenov YR.

J Immunother Cancer. 2021 Mar. 9(3). PMID: 33789879

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.

Carrot-Zhang J, Soca-Chafre G, Patterson N, Thorner AR, Nag A, Watson J, Genovese G, Rodriguez J, Gelbard MK, Corrales-Rodriguez L, Mitsuishi Y, Ha G, Campbell JD, Oxnard GR, Arrieta O, Cardona AF, Gusev A, Meyerson M.

Cancer Discov. 2021 Mar. 11(3):591-598. PMID: 33268447

Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations.

Nait Saada J, Kalantzis G, Shyr D, Cooper F, Robinson M, Gusev A, Palamara PF.

Nat Commun. 2020 11 30. 11(1):6130. PMID: 33257650

Prostate cancer reactivates developmental epigenomic programs during metastatic progression.

Pomerantz MM, Qiu X, Zhu Y, Takeda DY, Pan W, Baca SC, Gusev A, Korthauer KD, Severson TM, Ha G, Viswanathan SR, Seo JH, Nguyen HM, Zhang B, Pasaniuc B, Giambartolomei C, Alaiwi SA, Bell CA, O'Connor EP, Chabot MS, Stillman DR, Lis R, Font-Tello A, Li L, Cejas P, Bergman AM, Sanders J, van der Poel HG, Gayther SA, Lawrenson K, Fonseca MAS, Reddy J, Corona RI, Martovetsky G, Egan B, Choueiri T, Ellis L, Garraway IP, Lee GM, Corey E, Long HW, Zwart W, Freedman ML.

Nat Genet. 2020 08. 52(8):790-799. PMID: 32690948

Quantifying genetic effects on disease mediated by assayed gene expression levels.

Yao DW, O'Connor LJ, Price AL, Gusev A.

Nat Genet. 2020 06. 52(6):626-633. PMID: 32424349

Secure large-scale genome-wide association studies using homomorphic encryption.

Blatt M, Gusev A, Polyakov Y, Goldwasser S.

Proc Natl Acad Sci U S A. 2020 05 26. 117(21):11608-11613. PMID: 32398369

Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability.

van de Geijn B, Finucane H, Gazal S, Hormozdiari F, Amariuta T, Liu X, Gusev A, Loh PR, Reshef Y, Kichaev G, Raychauduri S, Price AL.

Hum Mol Genet. 2020 05 08. 29(7):1057-1067. PMID: 31595288

Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer.

Corona RI, Seo JH, Lin X, Hazelett DJ, Reddy J, Fonseca MAS, Abassi F, Lin YG, Mhawech-Fauceglia PY, Shah SP, Huntsman DG, Gusev A, Karlan BY, Berman BP, Freedman ML, Gayther SA, Lawrenson K.

Nat Commun. 2020 04 24. 11(1):2020. PMID: 32332753