Ana Arruda

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.

Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS.

bioRxiv. 2023 Feb 22. PMID: 36865319

Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.

Arruda AP, Parlakgül G.

Cold Spring Harb Perspect Biol. 2023 Feb 01. 15(2). PMID: 35940911

Integration of ER protein quality control mechanisms defines ß cell function and ER architecture.

Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen YJ, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L.

J Clin Invest. 2023 01 03. 133(1). PMID: 36346671

Regulation of liver subcellular architecture controls metabolic homeostasis.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS.

Nature. 2022 03. 603(7902):736-742. PMID: 35264794

Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity.

Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS.

Sci Signal. 2021 Dec 14. 14(713):eabf2059. PMID: 34905386

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS.

Cell Metab. 2021 Aug 03. 33(8):1716. PMID: 34348100

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS.

Cell Metab. 2021 02 02. 33(2):319-333.e6. PMID: 33340456

Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-analysis of randomised controlled trials.

Arruda APN, Zhang Y, Gomaa H, Bergamaschi CC, Guimaraes CC, Righesso LAR, Paglia MDG, Barberato-Filho S, Lopes LC, Ayala Melendez AP, de Oliveira LD, Paula-Ramos L, Johnston B, El Dib R.

BMJ Open. 2019 05 24. 9(5):e023729. PMID: 31129571

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS.

Nat Med. 2018 03. 24(3):292-303. PMID: 29400713

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity.

Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS.

Elife. 2017 12 15. 6. PMID: 29243589