Polyanions provide selective control of APC/C interactions with the activator subunit.
Mizrak A, Morgan DO.
Nat Commun. 2019 12 20. 10(1):5807. PMID: 31862931
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The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function.
Qin L, Mizrak A, Guimarães DSPSF, Tambrin HM, Morgan DO, Hall MC.
J Biol Chem. 2019 11 15. 294(46):17249-17261. PMID: 31562243
Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1.
Göke A, Schrott S, Mizrak A, Belyy V, Osman C, Walter P.
Mol Biol Cell. 2020 03 19. 31(7):527-545. PMID: 31532710
Genetic analysis reveals functions of atypical polyubiquitin chains.
Meza Gutierrez F, Simsek D, Mizrak A, Deutschbauer A, Braberg H, Johnson J, Xu J, Shales M, Nguyen M, Tamse-Kuehn R, Palm C, Steinmetz LM, Krogan NJ, Toczyski DP.
Elife. 2018 12 14. 7. PMID: 30547882
Quantitative framework for ordered degradation of APC/C substrates.
Lu D, Girard JR, Li W, Mizrak A, Morgan DO.
BMC Biol. 2015 Nov 16. 13:96. PMID: 26573515
Genetically engineered microvesicles carrying suicide mRNA/protein inhibit schwannoma tumor growth.
Mizrak A, Bolukbasi MF, Ozdener GB, Brenner GJ, Madlener S, Erkan EP, Ströbel T, Breakefield XO, Saydam O.
Mol Ther. 2013 Jan. 21(1):101-8. PMID: 22910294
miR-1289 and "Zipcode"-like Sequence Enrich mRNAs in Microvesicles.
Bolukbasi MF, Mizrak A, Ozdener GB, Madlener S, Ströbel T, Erkan EP, Fan JB, Breakefield XO, Saydam O.
Mol Ther Nucleic Acids. 2012 Feb 07. 1:e10. PMID: 23344721
miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.
Saydam O, Senol O, Würdinger T, Mizrak A, Ozdener GB, Stemmer-Rachamimov AO, Yi M, Stephens RM, Krichevsky AM, Saydam N, Brenner GJ, Breakefield XO.
Cancer Res. 2011 Feb 01. 71(3):852-61. PMID: 21156648
A novel imaging-compatible sciatic nerve schwannoma model.
Saydam O, Ozdener GB, Senol O, Mizrak A, Prabhakar S, Stemmer-Rachamimov AO, Breakefield XO, Brenner GJ.
J Neurosci Methods. 2011 Jan 30. 195(1):75-7. PMID: 21111000