Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.
Chitraju C, Fischer AW, Farese RV, Walther TC.
Cell Rep. 2020 Nov 03. 33(5):108348. PMID: 33147469
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Chandramohan Chitraju
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Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.
Bayerle A, Marsching C, Rabionet M, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Herzer S, Jennemann R, Levade T, Medin JA, Sandhoff R.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 09. 1865(9):158741. PMID: 32474112
Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.
Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC.
Hepatology. 2019 12. 70(6):1972-1985. PMID: 31081165
The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.
Chitraju C, Walther TC, Farese RV.
J Lipid Res. 2019 06. 60(6):1112-1120. PMID: 30936184
Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV.
Mol Cell. 2019 04 04. 74(1):32-44.e8. PMID: 30846318
Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.
Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV.
Cell Metab. 2017 Aug 01. 26(2):407-418.e3. PMID: 28768178
Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV.
J Lipid Res. 2017 06. 58(6):1230-1237. PMID: 28373485
Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC.
J Lipid Res. 2017 01. 58(1):226-235. PMID: 27836991
Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease.
Pal R, Ke Q, Pihan GA, Yesilaltay A, Penman ML, Wang L, Chitraju C, Kang PM, Krieger M, Kocher O.
2016 12 01. 311(6):H1392-H1408. PMID: 27694217
Seipin is required for converting nascent to mature lipid droplets.
Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV.
Elife. 2016 Aug 26. 5. PMID: 27564575