Chandramohan Chitraju

Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes.

Rabionet M, Bernard P, Pichery M, Marsching C, Bayerle A, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Asadi A, Ebel P, Hoekstra M, Dumas S, Ntambi JM, Jacobsson A, Willecke K, Medin JA, Jonca N, Sandhoff R.

Lipids. 2022 May. 57(3):183-195. PMID: 35318678

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.

Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Rydén M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Walther TC.

Dev Cell. 2022 02 07. 57(3):387-397.e4. PMID: 35134345

Conditional targeting of phosphatidylserine decarboxylase to lipid droplets.

Kumar S, Chitraju C, Farese RV, Walther TC, Burd CG.

Biol Open. 2021 03 03. 10(3). PMID: 33593792

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.

Chitraju C, Fischer AW, Farese RV, Walther TC.

Cell Rep. 2020 11 03. 33(5):108348. PMID: 33147469

Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.

Bayerle A, Marsching C, Rabionet M, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Herzer S, Jennemann R, Levade T, Medin JA, Sandhoff R.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 09. 1865(9):158741. PMID: 32474112

Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.

Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC.

Hepatology. 2019 12. 70(6):1972-1985. PMID: 31081165

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.

Chitraju C, Walther TC, Farese RV.

J Lipid Res. 2019 06. 60(6):1112-1120. PMID: 30936184

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.

Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV.

Mol Cell. 2019 04 04. 74(1):32-44.e8. PMID: 30846318

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV.

Cell Metab. 2017 Aug 01. 26(2):407-418.e3. PMID: 28768178

Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.

Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV.

J Lipid Res. 2017 06. 58(6):1230-1237. PMID: 28373485