Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice.
Shi Q, Carman CV, Chen Y, Sage PT, Xue F, Liang XM, Gilbert GE.
Blood Adv. 2020 05 26. 4(10):2272-2285. PMID: 32453842
Research Associates
Christopher Vincent Carman
Links
Overview
Major Research Interests: Adaptive & Innate Immune Cell Regulation and Trafficking
Specialties: Immunology, Inflammation, Vascular Biology, Immunomodulation, Bioengineering, Targeted Therapies
Our laboratory investigates the basic molecular and cell biological underpinnings of vascular inflammation and peripheral regulation of immune responses with special emphasis on leukocyte-endothelial interactions. Our studies also implement extensive molecular and cellular engineering approaches toward development of new immuno-modulation strategies for use in inflammatory, autoimmune, allogeneic and cancerous diseases.
Recently our studies have further focused on micro-environmental regulation of immunity and development of bioengineering approaches (e.g., in vitro chip, organoid and hypoxia technologies) as innovative platforms for studying tumor biology/immunology and for facilitating drug development.
Specific Topics we are currently investigating include:
The regulation of immune cell activation and migration
Peripheral regulation of adaptive and innate immune responses
Immuno-modulation of transplantation, autoimmunity and cancer
The cytoskeletal and biomechanical regulation of vascular integrity
B.S., 1994, Biochemistry
University of New Hampshire, Durham, N.H.
Ph.D., 1999, Molecular Pharmacology & Structural Biology
Thomas Jefferson University, Philadelphia, P.A.
Bibliography
Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis.
Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA.
ACS Nano. 2019 12 24. 13(12):13853-13865. PMID: 31479239
Edible Mushrooms Reduce Atherosclerosis in Ldlr-/- Mice Fed a High-Fat Diet.
Kim SH, Thomas MJ, Wu D, Carman CV, Ordovás JM, Meydani M.
J Nutr. 2019 08 01. 149(8):1377-1384. PMID: 31162580
The tumor suppressor p53 can promote collective cellular migration.
He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA, Park JA, Butler JP, Lu Q, Fredberg JJ.
PLoS One. 2019. 14(2):e0202065. PMID: 30707705
An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics.
Martinelli R, Carman CV.
J Vis Exp. 2015 Dec 24. (106):e53288. PMID: 26780561
T Lymphocyte-Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity.
Carman CV, Martinelli R.
Front Immunol. 2015. 6:603. PMID: 26635815
Actin foci facilitate activation of the phospholipase C-? in primary T lymphocytes via the WASP pathway.
Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML.
Elife. 2015 Mar 11. 4. PMID: 25758716
Intravital imaging of mesenchymal stem cell trafficking and association with platelets and neutrophils.
Teo GS, Yang Z, Carman CV, Karp JM, Lin CP.
Stem Cells. 2015 Jan. 33(1):265-77. PMID: 25263183
Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.
Sadow PM, Priolo C, Nanni S, Karreth FA, Duquette M, Martinelli R, Husain A, Clohessy J, Kutzner H, Mentzel T, Carman CV, Farsetti A, Henske EP, Palescandolo E, Macconaill LE, Chung S, Fadda G, Lombardi CP, De Angelis AM, Durante O, Parker JA, Pontecorvi A, Dvorak HF, Fletcher C, Pandolfi PP, Lawler J, Nucera C.
J Natl Cancer Inst. 2014 Aug. 106(8). PMID: 25063326
Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.
Martinelli R, Zeiger AS, Whitfield M, Sciuto TE, Dvorak A, Van Vliet KJ, Greenwood J, Carman CV.
J Cell Sci. 2014 Sep 01. 127(Pt 17):3720-34. PMID: 25002404