Collin Tokheim

In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target.

Wang X, Tokheim C, Gu SS, Wang B, Tang Q, Li Y, Traugh N, Zeng Z, Zhang Y, Li Z, Zhang B, Fu J, Xiao T, Li W, Meyer CA, Chu J, Jiang P, Cejas P, Lim K, Long H, Brown M, Liu XS.

Cell. 2021 Sep 20. PMID: 34582788

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade.

Gu SS, Zhang W, Wang X, Jiang P, Traugh N, Li Z, Meyer C, Stewig B, Xie Y, Bu X, Manos MP, Font-Tello A, Gjini E, Lako A, Lim K, Conway J, Tewari AK, Zeng Z, Sahu AD, Tokheim C, Weirather JL, Fu J, Zhang Y, Kroger B, Liang JH, Cejas P, Freeman GJ, Rodig S, Long HW, Gewurz BE, Hodi FS, Brown M, Liu XS.

Cancer Discov. 2021 Jun. 11(6):1524-1541. PMID: 33589424

Systematic characterization of mutations altering protein degradation in human cancers.

Tokheim C, Wang X, Timms RT, Zhang B, Mena EL, Wang B, Chen C, Ge J, Chu J, Zhang W, Elledge SJ, Brown M, Liu XS.

Mol Cell. 2021 03 18. 81(6):1292-1308.e11. PMID: 33567269

The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.

Makohon-Moore AP, Lipson EJ, Hooper JE, Zucker A, Hong J, Bielski CM, Hayashi A, Tokheim C, Baez P, Kappagantula R, Kohutek Z, Makarov V, Riaz N, Postow MA, Chapman PB, Karchin R, Socci ND, Solit DB, Chan TA, Taylor BS, Topalian SL, Iacobuzio-Donahue CA.

Clin Cancer Res. 2021 03 01. 27(5):1516-1525. PMID: 33323400

Cross-Site Concordance Evaluation of Tumor DNA and RNA Sequencing Platforms for the CIMAC-CIDC Network.

Zeng Z, Fu J, Cibulskis C, Jhaveri A, Gumbs C, Das B, Sanchez-Espiridion B, Janssens S, Taing L, Wang J, Lindsay J, Vilimas T, Zhang J, Tokheim C, Sahu A, Jiang P, Yan C, Duose DY, Cerami E, Chen L, Cohen D, Chen Q, Enos R, Huang X, Lee JJ, Liu Y, Neuberg DS, Nguyen C, Patterson C, Sarkar S, Shukla S, Tang M, Tsuji J, Uduman M, Wang X, Weirather JL, Yu J, Yu J, Zhang J, Zhang J, Meerzaman D, Thurin M, Futreal A, Karlovich C, Gabriel SB, Wistuba II, Liu XS, Wu CJ.

Clin Cancer Res. 2021 Sep 15. 27(18):5049-5061. PMID: 33323402

Clonal tracing reveals diverse patterns of response to immune checkpoint blockade.

Gu SS, Wang X, Hu X, Jiang P, Li Z, Traugh N, Bu X, Tang Q, Wang C, Zeng Z, Fu J, Meyer C, Zhang Y, Cejas P, Lim K, Wang J, Zhang W, Tokheim C, Sahu AD, Xing X, Kroger B, Ouyang Z, Long H, Freeman GJ, Brown M, Liu XS.

Genome Biol. 2020 10 15. 21(1):263. PMID: 33059736

Determinants of transcription factor regulatory range.

Chen CH, Zheng R, Tokheim C, Dong X, Fan J, Wan C, Tang Q, Brown M, Liu JS, Meyer CA, Liu XS.

Nat Commun. 2020 05 18. 11(1):2472. PMID: 32424124

Integrated Informatics Analysis of Cancer-Related Variants.

Pagel KA, Kim R, Moad K, Busby B, Zheng L, Tokheim C, Ryan M, Karchin R.

JCO Clin Cancer Inform. 2020 03. 4:310-317. PMID: 32228266

High-Throughput Prediction of MHC Class I and II Neoantigens with MHCnuggets.

Shao XM, Bhattacharya R, Huang J, Sivakumar IKA, Tokheim C, Zheng L, Hirsch D, Kaminow B, Omdahl A, Bonsack M, Riemer AB, Velculescu VE, Anagnostou V, Pagel KA, Karchin R.

Cancer Immunol Res. 2020 03. 8(3):396-408. PMID: 31871119

CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers.

Tokheim C, Karchin R.

Cell Syst. 2019 07 24. 9(1):9-23.e8. PMID: 31202631