Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane.
Kim S, Chung J, Arlt H, Pak AJ, Farese RV, Walther TC, Voth GA.
Elife. 2022 May 18. 11. PMID: 35583926
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Seipin forms a flexible cage at lipid droplet formation sites.
Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV, Walther TC.
Nat Struct Mol Biol. 2022 Mar. 29(3):194-202. PMID: 35210614
A Systematic Protein Turnover Map for Decoding Protein Degradation.
Christiano R, Arlt H, Kabatnik S, Mejhert N, Lai ZW, Farese RV, Walther TC.
Cell Rep. 2020 11 10. 33(6):108378. PMID: 33176155
Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.
Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC.
J Cell Biol. 2018 12 03. 217(12):4080-4091. PMID: 30327422
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC.
Mol Biol Cell. 2018 08 15. 29(17):2045-2054. PMID: 29949452
Retromer-driven membrane tubulation separates endosomal recycling from Rab7/Ypt7-dependent fusion.
Purushothaman LK, Arlt H, Kuhlee A, Raunser S, Ungermann C.
Mol Biol Cell. 2017 Mar 15. 28(6):783-791. PMID: 28100638
Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport.
Arlt H, Auffarth K, Kurre R, Lisse D, Piehler J, Ungermann C.
Mol Biol Cell. 2015 Apr 01. 26(7):1357-70. PMID: 25657322
The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome.
Balderhaar HJ, Arlt H, Ostrowicz C, Bröcker C, Sündermann F, Brandt R, Babst M, Ungermann C.
J Cell Sci. 2010 Dec 01. 123(Pt 23):4085-94. PMID: 21062894
The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.
Markgraf DF, Ahnert F, Arlt H, Mari M, Peplowska K, Epp N, Griffith J, Reggiori F, Ungermann C.
Mol Biol Cell. 2009 Dec. 20(24):5276-89. PMID: 19828734