Johan K. E. Spetz

Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities.

Spetz JKE, Florido MHC, Fraser CS, Qin X, Choiniere J, Yu SJ, Singh R, Friesen M, Rubin LL, Salem JE, Moslehi JJ, Sarosiek KA.

Sci Adv. 2022 Nov 11. 8(45):eabn6579. PMID: 36351019

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics.

Fraser CS, Spetz JKE, Qin X, Presser A, Choiniere J, Li C, Yu S, Blevins F, Hata AN, Miller JW, Bradshaw GA, Kalocsay M, Sanchorawala V, Sarosiek S, Sarosiek KA.

Nat Commun. 2022 Oct 02. 13(1):5789. PMID: 36184661

Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment.

Langen B, Vorontsov E, Spetz J, Swanpalmer J, Sihlbom C, Helou K, Forssell-Aronsson E.

Sci Rep. 2022 04 29. 12(1):7000. PMID: 35487913

Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I.

Larsson M, Rudqvist NP, Spetz J, Parris TZ, Langen B, Helou K, Forssell-Aronsson E.

Sci Rep. 2022 02 08. 12(1):2107. PMID: 35136135

Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate.

Romiani A, Spetz J, Shubbar E, Lind DE, Hallberg B, Palmer RH, Forssell-Aronsson E.

BMC Cancer. 2021 Aug 25. 21(1):950. PMID: 34433438

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.

Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA.

Sci Adv. 2021 08. 7(34). PMID: 34407940

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.

Daniels VW, Zoeller JJ, van Gastel N, McQueeney KE, Parvin S, Potter DS, Fell GG, Ferreira VG, Yilma B, Gupta R, Spetz J, Bhola PD, Endress JE, Harris IS, Carrilho E, Sarosiek KA, Scadden DT, Brugge JS, Letai A.

Sci Signal. 2021 06 08. 14(686). PMID: 34103421

Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure.

Larsson M, Rudqvist N, Spetz J, Shubbar E, Parris TZ, Langen B, Helou K, Forssell-Aronsson E.

PLoS One. 2020. 15(12):e0244098. PMID: 33382739

Biodistribution of 131I in mice is influenced by circadian variations.

Andersson CK, Elvborn M, Spetz JKE, Langen B, Forssell-Aronsson EB.

Sci Rep. 2020 09 23. 10(1):15541. PMID: 32968085

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity.

Inde Z, Yapp C, Joshi GN, Spetz J, Fraser C, Deskin B, Ghelfi E, Sodhi C, Hackam DJ, Kobzik L, Croker BA, Brownfield D, Jia H, Sarosiek KA.

bioRxiv. 2020 Sep 13. PMID: 32935109