Jonathan P Choiniere

Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities.

Spetz JKE, Florido MHC, Fraser CS, Qin X, Choiniere J, Yu SJ, Singh R, Friesen M, Rubin LL, Salem JE, Moslehi JJ, Sarosiek KA.

Sci Adv. 2022 11 11. 8(45):eabn6579. PMID: 36351019

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics.

Fraser CS, Spetz JKE, Qin X, Presser A, Choiniere J, Li C, Yu S, Blevins F, Hata AN, Miller JW, Bradshaw GA, Kalocsay M, Sanchorawala V, Sarosiek S, Sarosiek KA.

Nat Commun. 2022 10 02. 13(1):5789. PMID: 36184661

Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis.

Choiniere J, Lin MJ, Wang L, Wu J.

Liver Res. 2018 Jun. 2(2):100-107. PMID: 31815032

Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins.

Choiniere J, Wu J, Wang L.

Mol Pharmacol. 2017 03. 91(3):189-196. PMID: 28003426

Exposure to inorganic arsenic can lead to gut microbe perturbations and hepatocellular carcinoma.

Choiniere J, Wang L.

Acta Pharm Sin B. 2016 Sep. 6(5):426-429. PMID: 27709011

Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase G9a.

Zhang X, Wu J, Choiniere J, Yang Z, Huang Y, Bennett J, Wang L.

Toxicol Appl Pharmacol. 2016 08 01. 304:42-7. PMID: 27217333