Regulation of liver subcellular architecture controls metabolic homeostasis.
Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS.
Nature. 2022 03. 603(7902):736-742. PMID: 35264794
Other Positions
Director of the Sabri Ulker Center's Physiology Lab
Molecular Metabolism
Harvard T.H. Chan School of Public Health
Links
Bibliography
Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity.
Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS.
Sci Signal. 2021 Dec 14. 14(713):eabf2059. PMID: 34905386
A hormone complex of FABP4 and nucleoside kinases regulates islet function.
Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS.
Nature. 2021 12. 600(7890):720-726. PMID: 34880500
Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice.
Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GP.
Eur Heart J. 2020 07 07. 41(26):2456-2468. PMID: 31821481
The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.
Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS.
Sci Transl Med. 2019 04 24. 11(489). PMID: 31019023
TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.
Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M.
Diabetes. 2018 08. 67(8):1589-1603. PMID: 29871859
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS.
Nat Med. 2018 03. 24(3):292-303. PMID: 29400713
Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.
Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS.
Cell Rep. 2017 Oct 10. 21(2):393-402. PMID: 29020626
Increased oxidative phosphorylation in response to acute and chronic DNA damage.
Brace LE, Vose SC, Stanya K, Gathungu RM, Marur VR, Longchamp A, Treviño-Villarreal H, Mejia P, Vargas D, Inouye K, Bronson RT, Lee CH, Neilan E, Kristal BS, Mitchell JR.
NPJ Aging Mech Dis. 2016. 2:16022. PMID: 28721274
Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS.
Sci Transl Med. 2015 Dec 23. 7(319):319ra205. PMID: 26702093
News
Targeting ‘lipid chaperones’ may hold promise for lifelong preservation of metabolic health
Researchers have found that, in a mouse model, it may be possible to achieve lifelong metabolic health. The Harvard T.H. Chan School of Public Health scientists found that mice that lack fatty acid-binding proteins (FABPs) exhibit substantial protection…
Too much of a good thing: Excessive contact between cellular organelles disrupts metabolism in obesity
For immediate release: November 24, 2014 Boston, MA – Researchers at Harvard School of Public Health (HSPH) have found a novel mechanism causing type 2 diabetes that could be targeted to prevent or treat the disease. The research…
