Karen Inouye

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.

Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS.

bioRxiv. 2023 Feb 22. PMID: 36865319

Regulation of liver subcellular architecture controls metabolic homeostasis.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS.

Nature. 2022 03. 603(7902):736-742. PMID: 35264794

Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity.

Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS.

Sci Signal. 2021 Dec 14. 14(713):eabf2059. PMID: 34905386

A hormone complex of FABP4 and nucleoside kinases regulates islet function.

Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS.

Nature. 2021 12. 600(7890):720-726. PMID: 34880500

Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice.

Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GP.

Eur Heart J. 2020 07 07. 41(26):2456-2468. PMID: 31821481

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.

Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS.

Sci Transl Med. 2019 04 24. 11(489). PMID: 31019023

TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.

Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M.

Diabetes. 2018 08. 67(8):1589-1603. PMID: 29871859

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS.

Nat Med. 2018 03. 24(3):292-303. PMID: 29400713

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS.

Cell Rep. 2017 Oct 10. 21(2):393-402. PMID: 29020626

Increased oxidative phosphorylation in response to acute and chronic DNA damage.

Brace LE, Vose SC, Stanya K, Gathungu RM, Marur VR, Longchamp A, Treviño-Villarreal H, Mejia P, Vargas D, Inouye K, Bronson RT, Lee CH, Neilan E, Kristal BS, Mitchell JR.

NPJ Aging Mech Dis. 2016. 2:16022. PMID: 28721274