Karthik A Jagadeesh

Polygenic architecture of rare coding variation across 394,783 exomes.

Weiner DJ, Nadig A, Jagadeesh KA, Dey KK, Neale BM, Robinson EB, Karczewski KJ, O'Connor LJ.

Nature. 2023 Feb. 614(7948):492-499. PMID: 36755099

Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq.

Geiger-Schuller K, Eraslan B, Kuksenko O, Dey KK, Jagadeesh KA, Thakore PI, Karayel O, Yung AR, Rajagopalan A, Meireles AM, Yang KD, Amir-Zilberstein L, Delorey T, Phillips D, Raychowdhury R, Moussion C, Price AL, Hacohen N, Doench JG, Uhler C, Rozenblatt-Rosen O, Regev A.

bioRxiv. 2023 Jan 24. PMID: 36747789

Publisher Correction: SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests.

Zhou W, Bi W, Zhao Z, Dey KK, Jagadeesh KA, Karczewski KJ, Daly MJ, Neale BM, Lee S.

Nat Genet. 2022 Nov. 54(11):1755. PMID: 36257984

Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics.

Jagadeesh KA, Dey KK, Montoro DT, Mohan R, Gazal S, Engreitz JM, Xavier RJ, Price AL, Regev A.

Nat Genet. 2022 10. 54(10):1479-1492. PMID: 36175791

SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests.

Zhou W, Bi W, Zhao Z, Dey KK, Jagadeesh KA, Karczewski KJ, Daly MJ, Neale BM, Lee S.

Nat Genet. 2022 10. 54(10):1466-1469. PMID: 36138231

Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution.

Shiau C, Su J, Guo JA, Hong TS, Wo JY, Jagadeesh KA, Hwang WL.

Front Oncol. 2022. 12:929950. PMID: 36185212

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data.

Zhang MJ, Hou K, Dey KK, Sakaue S, Jagadeesh KA, Weinand K, Taychameekiatchai A, Rao P, Pisco AO, Zou J, Wang B, Gandal M, Raychaudhuri S, Pasaniuc B, Price AL.

Nat Genet. 2022 10. 54(10):1572-1580. PMID: 36050550

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A.

Nat Genet. 2022 08. 54(8):1178-1191. PMID: 35902743

Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity.

Gazal S, Weissbrod O, Hormozdiari F, Dey KK, Nasser J, Jagadeesh KA, Weiner DJ, Shi H, Fulco CP, O'Connor LJ, Pasaniuc B, Engreitz JM, Price AL.

Nat Genet. 2022 06. 54(6):827-836. PMID: 35668300

Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human genetics.