Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K, Camargo CA, Liang L.
Eur Respir J. 2019 12. 54(6). PMID: 31619474
Faculty Affiliate in the Department of Biostatistics
Biostatistics
Harvard T.H. Chan School of Public Health
My group focuses on developing the computational and statistical tools for analyses of multi-omics data to understand the biological mechanism for diseases and provide prediction model to assess future risk and individual benefit for intervention. We are currently looking for dedicated students (MS or PHD) for the following projects:
(1) Polygenic risk prediction model for complex diseases and traits applicable to multiple populations. The method will be evaluated and applied to biobank scale genome-wide association studies from European, African and Asian populations.
(2) Estimation of shared genetic components between complex diseases and traits by incorporating data of common and rare variants from multiple populations.
(3) Metabolomic network analysis for diseases and dietary exposure using targeted and untargeted metabolites from mass-spectrometry based metabolomics data.
(4) DNA methylation signature for aging and risk for childhood diseases (obesity and asthma) and its interaction with intervention and environmental exposures.
(5) Mapping of genetic variants for gene expression, methylation, metabolomics and other secondary traits (QTL mapping). Causal inference based on robust Mendelian randomization framework under different genetic architectures.
We actively apply these methods to large scale studies and unique longitudinal cohorts focus on Asthma, Allergy, Lung Cancer, COPD, Age-Related Macular Degeneration (AMD), Diabetes, Heart Diseases and other cardiometabolic traits with study subjects from European, African, Hispanic and Asian populations.
Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K, Camargo CA, Liang L.
Eur Respir J. 2019 12. 54(6). PMID: 31619474
Ma B, Huang J, Liang L.
Database (Oxford). 2014. 2014. PMID: 25037307
Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Purcell SM, Haas DW, Liang L, Sunyaev S, Patterson N, de Bakker PI, Reich D, Price AL.
Nat Genet. 2012 May 20. 44(6):631-5. PMID: 22610117
Salm MP, Horswell SD, Hutchison CE, Speedy HE, Yang X, Liang L, Schadt EE, Cookson WO, Wierzbicki AS, Naoumova RP, Shoulders CC.
Genome Res. 2012 Jun. 22(6):1144-53. PMID: 22399572
Qi Q, Liang L, Doria A, Hu FB, Qi L.
Diabetes. 2012 Mar. 61(3):745-52. PMID: 22315312
Edgren G, Liang L, Adami HO, Chang ET.
Eur J Epidemiol. 2012 Mar. 27(3):187-96. PMID: 22212865
Cornelis MC, Tchetgen EJ, Liang L, Qi L, Chatterjee N, Hu FB, Kraft P.
Am J Epidemiol. 2012 Feb 01. 175(3):191-202. PMID: 22199026
Zhang M, Liang L, Morar N, Dixon AL, Lathrop GM, Ding J, Moffatt MF, Cookson WO, Kraft P, Qureshi AA, Han J.
Hum Genet. 2012 Apr. 131(4):615-23. PMID: 22006220
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS.
Nat Genet. 2011 Oct 16. 43(11):1131-8. PMID: 22001757
Zhang Y, Li Y, Lai J, Zhang H, Liu Y, Liang L, Xie Q.
Mol Biol Rep. 2012 Apr. 39(4):4627-33. PMID: 21947846
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