Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.
Deshycka R, Sudaryo V, Huang NJ, Xie Y, Smeding LY, Choi MK, Ploegh HL, Lodish HF, Pishesha N.
PLoS One. 2021. 16(11):e0259353. PMID: 34731223
Research Fellows
Novalia Pishesha
Other Positions
Junior Fellow of the Society of Fellows
Society of Fellows -Other Academic
Harvard Faculty of Arts and Sciences
Instructor in Pediatrics
Pediatrics-Boston Children's Hospital
Harvard Medical School
Links
Bibliography
Noninvasive Immuno-PET Imaging of CD8+ T Cell Behavior in Influenza A Virus-Infected Mice.
Rothlauf PW, Li Z, Pishesha N, Xie YJ, Woodham AW, Bousbaine D, Kolifrath SC, Verschoor VL, Ploegh HL.
Front Immunol. 2021. 12:777739. PMID: 34804069
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants.
Pishesha N, Harmand TJ, Rothlauf PW, Praest P, Alexander RK, van den Doel R, Liebeskind MJ, Vakaki MA, McCaul N, Wijne C, Verhaar E, Pinney W, Heston H, Bloyet LM, Pontelli MC, Ilagan MXG, Jan Lebbink R, Buchser WJ, Wiertz EJHJ, Whelan SPJ, Ploegh HL.
Proc Natl Acad Sci U S A. 2021 11 02. 118(44). PMID: 34654739
Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.
Ayukawa S, Kamoshita N, Nakayama J, Teramoto R, Pishesha N, Ohba K, Sato N, Kozawa K, Abe H, Semba K, Goda N, Fujita Y, Maruyama T.
Nat Immunol. 2021 11. 22(11):1391-1402. PMID: 34686865
An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance.
Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL.
Proc Natl Acad Sci U S A. 2021 08 24. 118(34). PMID: 34417313
Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4+ T Cells.
Islam A, Pishesha N, Harmand TJ, Heston H, Woodham AW, Cheloha RW, Bousbaine D, Rashidian M, Ploegh HL.
J Immunol. 2021 09 01. 207(5):1468-1477. PMID: 34408009
Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells.
Harmand TJ, Pishesha N, Rehm FBH, Ma W, Pinney WB, Xie YJ, Ploegh HL.
ACS Chem Biol. 2021 07 16. 16(7):1201-1207. PMID: 34129316
Induction of antigen-specific tolerance by nanobody-antigen adducts that target class-II major histocompatibility complexes.
Pishesha N, Harmand T, Smeding LY, Ma W, Ludwig LS, Janssen R, Islam A, Xie YJ, Fang T, McCaul N, Pinney W, Sugito HR, Rossotti MA, Gonzalez-Sapienza G, Ploegh HL.
Nat Biomed Eng. 2021 11. 5(11):1389-1401. PMID: 34127819
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA.
Immunity. 2021 06 08. 54(6):1186-1199.e7. PMID: 33915108
Nanobodies as in vivo, non-invasive, imaging agents.
Harmand TJ, Islam A, Pishesha N, Ploegh HL.
RSC Chem Biol. 2021 Mar 08. 2(3):685-701. PMID: 34212147