A guide to antigen processing and presentation.
Pishesha N, Harmand TJ, Ploegh HL.
Nat Rev Immunol. 2022 Apr 13. PMID: 35418563
Novalia Pishesha
Junior Fellow of the Society of Fellows
Society of Fellows -Other Academic
Other Positions
Instructor in Pediatrics
Pediatrics-Boston Children's Hospital
Harvard Medical School
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Bibliography
Functional analyses and single cell immunoprofiling uncover sex-specific differences in SARS-CoV2 immune memory development.
Eraslan B, Brown E, Benson M, Amir-Zilberstein L, Park SM, Tusi B, Pokatayev V, Hecht C, Pishesha N, Phillips D, Kim A, Zhang S, Gaca A, Ghantous F, Delorey T, Livny J, Baden L, Rozenblatt-Rosen O, Graham D, Regev A, Seaman M, Woolley A, Cosimi L, Hung D, Deguine J, Xavier R.
Res Sq. 2022 Mar 15. PMID: 35313592
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I.
Cell. 2022 02 17. 185(4):614-629.e21. PMID: 35148840
Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.
Deshycka R, Sudaryo V, Huang NJ, Xie Y, Smeding LY, Choi MK, Ploegh HL, Lodish HF, Pishesha N.
PLoS One. 2021. 16(11):e0259353. PMID: 34731223
Noninvasive Immuno-PET Imaging of CD8+ T Cell Behavior in Influenza A Virus-Infected Mice.
Rothlauf PW, Li Z, Pishesha N, Xie YJ, Woodham AW, Bousbaine D, Kolifrath SC, Verschoor VL, Ploegh HL.
Front Immunol. 2021. 12:777739. PMID: 34804069
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants.
Pishesha N, Harmand TJ, Rothlauf PW, Praest P, Alexander RK, van den Doel R, Liebeskind MJ, Vakaki MA, McCaul N, Wijne C, Verhaar E, Pinney W, Heston H, Bloyet LM, Pontelli MC, Ilagan MXG, Jan Lebbink R, Buchser WJ, Wiertz EJHJ, Whelan SPJ, Ploegh HL.
Proc Natl Acad Sci U S A. 2021 11 02. 118(44). PMID: 34654739
Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.
Ayukawa S, Kamoshita N, Nakayama J, Teramoto R, Pishesha N, Ohba K, Sato N, Kozawa K, Abe H, Semba K, Goda N, Fujita Y, Maruyama T.
Nat Immunol. 2021 11. 22(11):1391-1402. PMID: 34686865
An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance.
Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL.
Proc Natl Acad Sci U S A. 2021 08 24. 118(34). PMID: 34417313
Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4+ T Cells.
Islam A, Pishesha N, Harmand TJ, Heston H, Woodham AW, Cheloha RW, Bousbaine D, Rashidian M, Ploegh HL.
J Immunol. 2021 09 01. 207(5):1468-1477. PMID: 34408009
Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells.
Harmand TJ, Pishesha N, Rehm FBH, Ma W, Pinney WB, Xie YJ, Ploegh HL.
ACS Chem Biol. 2021 07 16. 16(7):1201-1207. PMID: 34129316