Novalia Pishesha

An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance.

Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL.

Proc Natl Acad Sci U S A. 2021 Aug 24. 118(34). PMID: 34417313

Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4+ T Cells.

Islam A, Pishesha N, Harmand TJ, Heston H, Woodham AW, Cheloha RW, Bousbaine D, Rashidian M, Ploegh HL.

J Immunol. 2021 09 01. 207(5):1468-1477. PMID: 34408009

Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells.

Harmand TJ, Pishesha N, Rehm FBH, Ma W, Pinney WB, Xie YJ, Ploegh HL.

ACS Chem Biol. 2021 07 16. 16(7):1201-1207. PMID: 34129316

Induction of antigen-specific tolerance by nanobody-antigen adducts that target class-II major histocompatibility complexes.

Pishesha N, Harmand T, Smeding LY, Ma W, Ludwig LS, Janssen R, Islam A, Xie YJ, Fang T, McCaul N, Pinney W, Sugito HR, Rossotti MA, Gonzalez-Sapienza G, Ploegh HL.

Nat Biomed Eng. 2021 Jun 14. PMID: 34127819

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.

Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA.

Immunity. 2021 06 08. 54(6):1186-1199.e7. PMID: 33915108

Nanobodies as in vivo, non-invasive, imaging agents.

Harmand TJ, Islam A, Pishesha N, Ploegh HL.

RSC Chem Biol. 2021 Mar 08. 2(3):685-701. PMID: 34212147

Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments.

Xie YJ, Dougan M, Ingram JR, Pishesha N, Fang T, Momin N, Ploegh HL.

Cancer Immunol Res. 2020 04. 8(4):518-529. PMID: 32019780

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice.

Xie YJ, Dougan M, Jailkhani N, Ingram J, Fang T, Kummer L, Momin N, Pishesha N, Rickelt S, Hynes RO, Ploegh H.

Proc Natl Acad Sci U S A. 2019 04 16. 116(16):7624-7631. PMID: 30936321

Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome.

Liu FD, Tam K, Pishesha N, Poon Z, Van Vliet KJ.

Stem Cell Res Ther. 2018 10 24. 9(1):268. PMID: 30352620

Sortase A: A Model for Transpeptidation and Its Biological Applications.

Pishesha N, Ingram JR, Ploegh HL.

Annu Rev Cell Dev Biol. 2018 10 06. 34:163-188. PMID: 30110557