Novalia Pishesha

Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms.

Pishesha N, Harmand T, Carpenet C, Liu X, Bhan A, Islam A, van den Doel R, Pinney W, Ploegh HL.

Proc Natl Acad Sci U S A. 2022 10 25. 119(43):e2211065119. PMID: 36252038

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.

Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW.

Sci Immunol. 2022 10 28. 7(76):eadd5446. PMID: 35951767

A guide to antigen processing and presentation.

Pishesha N, Harmand TJ, Ploegh HL.

Nat Rev Immunol. 2022 12. 22(12):751-764. PMID: 35418563

Functional analyses and single cell immunoprofiling uncover sex-specific differences in SARS-CoV2 immune memory development.

Eraslan B, Brown E, Benson M, Amir-Zilberstein L, Park SM, Tusi B, Pokatayev V, Hecht C, Pishesha N, Phillips D, Kim A, Zhang S, Gaca A, Ghantous F, Delorey T, Livny J, Baden L, Rozenblatt-Rosen O, Graham D, Regev A, Seaman M, Woolley A, Cosimi L, Hung D, Deguine J, Xavier R.

Res Sq. 2022 Mar 15. PMID: 35313592

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.

Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I.

Cell. 2022 02 17. 185(4):614-629.e21. PMID: 35148840

Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.

Deshycka R, Sudaryo V, Huang NJ, Xie Y, Smeding LY, Choi MK, Ploegh HL, Lodish HF, Pishesha N.

PLoS One. 2021. 16(11):e0259353. PMID: 34731223

Noninvasive Immuno-PET Imaging of CD8+ T Cell Behavior in Influenza A Virus-Infected Mice.

Rothlauf PW, Li Z, Pishesha N, Xie YJ, Woodham AW, Bousbaine D, Kolifrath SC, Verschoor VL, Ploegh HL.

Front Immunol. 2021. 12:777739. PMID: 34804069

A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants.

Pishesha N, Harmand TJ, Rothlauf PW, Praest P, Alexander RK, van den Doel R, Liebeskind MJ, Vakaki MA, McCaul N, Wijne C, Verhaar E, Pinney W, Heston H, Bloyet LM, Pontelli MC, Ilagan MXG, Jan Lebbink R, Buchser WJ, Wiertz EJHJ, Whelan SPJ, Ploegh HL.

Proc Natl Acad Sci U S A. 2021 11 02. 118(44). PMID: 34654739

Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.

Ayukawa S, Kamoshita N, Nakayama J, Teramoto R, Pishesha N, Ohba K, Sato N, Kozawa K, Abe H, Semba K, Goda N, Fujita Y, Maruyama T.

Nat Immunol. 2021 11. 22(11):1391-1402. PMID: 34686865

An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance.

Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL.

Proc Natl Acad Sci U S A. 2021 08 24. 118(34). PMID: 34417313