Pardis Sabeti
Other Academic

Pardis Sabeti

Professor of Immunology and Infectious Diseases

Immunology and Infectious Diseases

pardis@broadinstitute.org


Overview

Dr. Sabeti's lab focuses on developing new analytical and genomic methods to study evolutionary adaptation and genetic diversity in humans and pathogens, with three current research foci: (1) Identifying and characterizing the underlying adaptive changes that have shaped the human species over time; and (2) Investigating genetic diversity in pathogens such as Lassa virus, Ebola virus, Zika virus, and Babesia microti, towards improved diagnostics, surveillance, and interventions, and (3) Developing novels tools to detect and diagnose microbes causing human morbidity and mortality.


Bibliography

Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

Lemieux JE, Siddle KJ, Shaw BM, Loreth C, Schaffner SF, Gladden-Young A, Adams G, Fink T, Tomkins-Tinch CH, Krasilnikova LA, DeRuff KC, Rudy M, Bauer MR, Lagerborg KA, Normandin E, Chapman SB, Reilly SK, Anahtar MN, Lin AE, Carter A, Myhrvold C, Kemball ME, Chaluvadi S, Cusick C, Flowers K, Neumann A, Cerrato F, Farhat M, Slater D, Harris JB, Branda JA, Hooper D, Gaeta JM, Baggett TP, O'Connell J, Gnirke A, Lieberman TD, Philippakis A, Burns M, Brown CM, Luban J, Ryan ET, Turbett SE, LaRocque RC, Hanage WP, Gallagher GR, Madoff LC, Smole S, Pierce VM, Rosenberg E, Sabeti PC, Park DJ, MacInnis BL.

Science. 2020 Dec 10. PMID: 33303686

Epidemiological and immunological features of obesity and SARS-CoV-2.

Nilles EJ, Siddiqui SM, Fischinger S, Bartsch YC, de Saint Aubin M, Zhou G, Gluck M, Berger S, Rhee J, Petersen E, Mormann B, Loesche M, Chen Z, Yu J, Gebre M, Atyeo C, Gorman MJ, Zhu AL, Burke J, Slein M, Hasdianda MA, Jambaulikar G, Boyer E, Sabeti P, Barouch DH, Julg BD, Kucharski AJ, Musk ER, Lauffenburger DA, Alter G, Menon AS.

medRxiv. 2020 Nov 13. PMID: 33200139

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Wang L, Sinnott-Armstrong N, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, Tallapragada DSP, Strobel SM, Lee MJ, Tewhey R, Sabeti PC, Schaefer A, Petri A, Kauppinen S, Chung RT, Soukas A, Avruch J, Fried SK, Hauner H, Sadreyev RI, Shulman GI, Claussnitzer M, Näär AM.

Cell. 2020 Oct 29. 183(3):684-701.e14. PMID: 33058756


News

Connecting young students with real-world scientists

Two Harvard Chan School faculty members and one alumna are among 22 experts featured in a project called “I Am A Scientist,” which aims to promote STEM diversity by providing middle- and high-school students with information about modern-day…

Waning immunity allowed Massachusetts mumps outbreaks

In 2016 and 2017, the number of mumps cases in Massachusetts was 250 and 170, respectively, a large increase from the average of 10 cases annually in the state. Most patients in these outbreaks had been vaccinated, and…