Po-Ru Loh

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer.

Natarajan P, Zekavat S, Lin SH, Bick A, Liu A, Paruchuri K, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Pirruccello J, Pampana A, Loh PR, Kohli P, McCarroll S, Neale B, Engels E, Brown D, Smoller J, Green R, Karlson E, Lebo M, Ellinor P, Weiss S, Daly M, Terao C, Zhao H, Ebert B, Machiela M, Genovese G.

Res Sq. 2020 Nov 16. PMID: 33236004

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer.

Zekavat SM, Lin SH, Bick AG, Liu A, Paruchuri K, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Pirruccello JP, Pampana A, Loh PR, Kohli P, McCarroll SA, Neale B, Engels EA, Brown DW, Smoller JW, Green R, Karlson EW, Lebo M, Ellinor PT, Weiss ST, Daly MJ, Terao C, Zhao H, Ebert BL, Ganna A, Machiela MJ, Genovese G, Natarajan P.

medRxiv. 2020 Nov 16. PMID: 33236019

Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes.

Brown DW, Lin SH, Loh PR, Chanock SJ, Savage SA, Machiela MJ.

PLoS Genet. 2020 10. 16(10):e1009078. PMID: 33090998

Monogenic and polygenic inheritance become instruments for clonal selection.

Loh PR, Genovese G, McCarroll SA.

Nature. 2020 08. 584(7819):136-141. PMID: 32581363

Chromosomal alterations among age-related haematopoietic clones in Japan.

Terao C, Suzuki A, Momozawa Y, Akiyama M, Ishigaki K, Yamamoto K, Matsuda K, Murakami Y, McCarroll SA, Kubo M, Loh PR, Kamatani Y.

Nature. 2020 08. 584(7819):130-135. PMID: 32581364

Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability.

van de Geijn B, Finucane H, Gazal S, Hormozdiari F, Amariuta T, Liu X, Gusev A, Loh PR, Reshef Y, Kichaev G, Raychauduri S, Price AL.

Hum Mol Genet. 2020 May 08. 29(7):1057-1067. PMID: 31595288

Liability threshold modeling of case-control status and family history of disease increases association power.

Hujoel MLA, Gazal S, Loh PR, Patterson N, Price AL.

Nat Genet. 2020 05. 52(5):541-547. PMID: 32313248

Genes with High Network Connectivity Are Enriched for Disease Heritability.

Kim SS, Dai C, Hormozdiari F, van de Geijn B, Gazal S, Park Y, O'Connor L, Amariuta T, Loh PR, Finucane H, Raychaudhuri S, Price AL.

Am J Hum Genet. 2019 Dec 05. 105(6):1302. PMID: 31809749

Genetic predisposition to mosaic Y chromosome loss in blood.

Thompson DJ, Genovese G, Halvardson J, Ulirsch JC, Wright DJ, Terao C, Davidsson OB, Day FR, Sulem P, Jiang Y, Danielsson M, Davies H, Dennis J, Dunlop MG, Easton DF, Fisher VA, Zink F, Houlston RS, Ingelsson M, Kar S, Kerrison ND, Kinnersley B, Kristjansson RP, Law PJ, Li R, Loveday C, Mattisson J, McCarroll SA, Murakami Y, Murray A, Olszewski P, Rychlicka-Buniowska E, Scott RA, Thorsteinsdottir U, Tomlinson I, Moghadam BT, Turnbull C, Wareham NJ, Gudbjartsson DF, Kamatani Y, Hoffmann ER, Jackson SP, Stefansson K, Auton A, Ong KK, Machiela MJ, Loh PR, Dumanski JP, Chanock SJ, Forsberg LA, Perry JRB.

Nature. 2019 11. 575(7784):652-657. PMID: 31748747

Fast, sensitive and accurate integration of single-cell data with Harmony.

Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, Baglaenko Y, Brenner M, Loh PR, Raychaudhuri S.

Nat Methods. 2019 12. 16(12):1289-1296. PMID: 31740819