Renata L.S. Goncalves

Biography

Publications

• CoQ imbalance drives reverse electron transport to disrupt liver metabolism.

  Goncalves RLS, Wang ZB, Riveros JK, Parlakgül G, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Hui ST, Coll M, Arruda AP, Burgess SC, Graupera I, Hotamisligil GS. Nature 2025 07

  PMID: 40437093

• Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.

  Parlakgül G, Pang S, Artico LL, Min N, Cagampan E, Villa R, Goncalves RLS, Lee GY, Xu CS, Hotamisligil GS, Arruda AP. Nat Commun 2024 May 10

  PMID: 38729945

• Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.

  Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS. bioRxiv 2023 Feb 22

  PMID: 36865319

• Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H2 O2 production in heart and skeletal muscle mitochondria.

  Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamisligil GS. FEBS Lett 2021 02

  PMID: 33112430

• TMEM2 Modulates ER Stress in a Non-canonical Manner.

  Goncalves RLS, Hotamisligil GS. Cell Metab 2019 12 03

  PMID: 31801059