Rory D Kirchner

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.

Prokopenko D, Morgan SL, Mullin K, Hofmann O, Chapman B, Kirchner R, Amberkar S, Wohlers I, Lange C, Hide W, Bertram L, Tanzi RE.

Alzheimers Dement. 2021 Apr 02. PMID: 33797837

Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus.

Neuhausser WM, Oh HS, Eggan P, Angelova M, Kirchner R, Eggan KC, Knipe DM.

Bio Protoc. 2020 Sep 05. 10(17):e3748. PMID: 33659408

Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data.

Prokopenko D, Hecker J, Kirchner R, Chapman BA, Hoffman O, Mullin K, Hide W, Bertram L, Laird N, DeMeo DL, Lange C, Tanzi RE.

Sci Rep. 2020 03 19. 10(1):5029. PMID: 32193444

A cell atlas of the adult Drosophila midgut.

Hung RJ, Hu Y, Kirchner R, Liu Y, Xu C, Comjean A, Tattikota SG, Li F, Song W, Ho Sui S, Perrimon N.

Proc Natl Acad Sci U S A. 2020 01 21. 117(3):1514-1523. PMID: 31915294

Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9.

Oh HS, Neuhausser WM, Eggan P, Angelova M, Kirchner R, Eggan KC, Knipe DM.

Elife. 2019 12 02. 8. PMID: 31789594

Supporting Single Cell RNA-seq Analysis at Harvard - A Community Approach.

Sui SH, Kirchner R, Steinbaugh M, Boswell S, Piper M, Barrera V, Pantano L, Khetani R, Mistry M, Rutherford K, Hutchinson J.

J Biomol Tech. 2019 Dec. 30(Suppl):S39. PMID: 31896961

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.

Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K.

Nat Neurosci. 2019 02. 22(2):167-179. PMID: 30643292

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex.

Poulopoulos A, Murphy AJ, Ozkan A, Davis P, Hatch J, Kirchner R, Macklis JD.

Nature. 2019 01. 565(7739):356-360. PMID: 30626971

Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement.

Kalish BT, Cheadle L, Hrvatin S, Nagy MA, Rivera S, Crow M, Gillis J, Kirchner R, Greenberg ME.

Proc Natl Acad Sci U S A. 2018 01 30. 115(5):E1051-E1060. PMID: 29343640

Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment.

Li A, Hooli B, Mullin K, Tate RE, Bubnys A, Kirchner R, Chapman B, Hofmann O, Hide W, Tanzi RE.

Hum Mol Genet. 2017 04 15. 26(8):1472-1482. PMID: 28186563