Tobias Walther is professor of Molecular Metabolism, Executive Director of the Harvard Chan School of Public Health Analytics Center (ChAMP), Director of the Center on Causes and Prevention of Cardiovascular Disease, and an Investigator at the Howard Hughes Medical Institute. After obtaining his Ph.D. at the European Molecular Biology Laboratory (EMBL), Dr. Walther did his postdoctoral training under Peter Walter at UCSF. Dr. Walther went on to lead labs at the Max Planck Institute of Biochemistry and the Yale School of Medicine. In 2014, Dr. Walter established a joint laboratory with Dr. Robert Farese, Jr. at Harvard.
Research
The Farese-Walther laboratory focuses on how cells detect changes in membrane lipids and respond to these changes by regulating their metabolism and cell biology. Current projects include investigating the mechanism underlying neutral lipid storage and the cell biology of cytosolic lipid droplets. Other areas of focus include studying the regulation of lipid homeostasis and how it contributes to physiology and disease.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV.
Nat Commun. 2022 Oct 07. 13(1):5924. PMID: 36207292
Farese RV, Walther TC.
Cold Spring Harb Perspect Biol. 2022 Sep 12. PMID: 36096640
Song J, Mizrak A, Lee CW, Cicconet M, Lai ZW, Tang WC, Lu CH, Mohr SE, Farese RV, Walther TC.
Nat Cell Biol. 2022 09. 24(9):1364-1377. PMID: 36050470
Kim S, Chung J, Arlt H, Pak AJ, Farese RV, Walther TC, Voth GA.
Elife. 2022 05 18. 11. PMID: 35583926
Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV, Walther TC.
Nat Struct Mol Biol. 2022 03. 29(3):194-202. PMID: 35210614
Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Rydén M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Walther TC.
Dev Cell. 2022 02 07. 57(3):387-397.e4. PMID: 35134345
Kim S, Li C, Farese RV, Walther TC, Voth GA.
J Phys Chem B. 2022 01 20. 126(2):453-462. PMID: 34990551
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF.
Nature. 2021 Nov. 599(7885):E5. PMID: 34732896
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF.
Nature. 2021 11. 599(7883):147-151. PMID: 34616045
Olarte MJ, Swanson JMJ, Walther TC, Farese RV.
Trends Biochem Sci. 2022 01. 47(1):39-51. PMID: 34583871
Bob Farese Jr. is an expert in how lipid synthesis and storage may lead to disease—and an accomplished amateur photographer.
Quick updates about the latest public health news from across the School and beyond.
For immediate release: April 13, 2020 Boston, MA – Disrupting the production of a class of lipids known as sphingolipids in neurons improved symptoms of neurodegeneration and increased survival in a mouse model, according to new research led…
November 27, 2019—Scientists across Harvard T.H. Chan School of Public Health got a major upgrade to their toolbox this week with the official launch of the Harvard Chan Advanced Multi-omics Platform, or ChAMP. Housed in the Department of…
For immediate release: April 4, 2019 New research led by Harvard T.H. Chan School of Public Health has identified numerous genes that influence how cells respond to saturated fatty acids. Some of these genes have promise as potential…
