Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane.
Kim S, Chung J, Arlt H, Pak AJ, Farese RV, Walther TC, Voth GA.
Elife. 2022 May 18. 11. PMID: 35583926
Executive Director of the Harvard T.H. Chan School of Public Health Analytics Center
Molecular Metabolism
Harvard T.H. Chan School of Public Health
Director, Center on Causes and Prevention for Cardiovascular Disease
Molecular Metabolism
Harvard T.H. Chan School of Public Health
Professor of Cell Biology
Cell Biology
Harvard Medical School
Tobias Walther is professor of Molecular Metabolism, Executive Director of the Harvard Chan School of Public Health Analytics Center (ChAMP), Director of the Center on Causes and Prevention of Cardiovascular Disease, and an Investigator at the Howard Hughes Medical Institute. After obtaining his Ph.D. at the European Molecular Biology Laboratory (EMBL), Dr. Walther did his postdoctoral training under Peter Walter at UCSF. Dr. Walther went on to lead labs at the Max Planck Institute of Biochemistry and the Yale School of Medicine. In 2014, Dr. Walter established a joint laboratory with Dr. Robert Farese, Jr. at Harvard.
Research
The Farese-Walther laboratory focuses on how cells detect changes in membrane lipids and respond to these changes by regulating their metabolism and cell biology. Current projects include investigating the mechanism underlying neutral lipid storage and the cell biology of cytosolic lipid droplets. Other areas of focus include studying the regulation of lipid homeostasis and how it contributes to physiology and disease.
Kim S, Chung J, Arlt H, Pak AJ, Farese RV, Walther TC, Voth GA.
Elife. 2022 May 18. 11. PMID: 35583926
Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV, Walther TC.
Nat Struct Mol Biol. 2022 Mar. 29(3):194-202. PMID: 35210614
Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Rydén M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Walther TC.
Dev Cell. 2022 02 07. 57(3):387-397.e4. PMID: 35134345
Kim S, Li C, Farese RV, Walther TC, Voth GA.
J Phys Chem B. 2022 01 20. 126(2):453-462. PMID: 34990551
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF.
Nature. 2021 Nov. 599(7885):E5. PMID: 34732896
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF.
Nature. 2021 11. 599(7883):147-151. PMID: 34616045
Olarte MJ, Swanson JMJ, Walther TC, Farese RV.
Trends Biochem Sci. 2022 01. 47(1):39-51. PMID: 34583871
Kumar S, Chitraju C, Farese RV, Walther TC, Burd CG.
Biol Open. 2021 03 03. 10(3). PMID: 33593792
Bainter W, Platt CD, Park SY, Stafstrom K, Wallace JG, Peters ZT, Massaad MJ, Becuwe M, Salinas SA, Jones J, Beaussant-Cohen S, Jaber F, Yang JS, Walther TC, Orange JS, Rao C, Rakoff-Nahoum S, Tsokos M, Naseem SUR, Al-Tamemi S, Chou J, Hsu VW, Geha RS.
J Clin Invest. 2021 02 01. 131(3). PMID: 33529166
Farese RV, Walther TC.
J Clin Invest. 2021 01 19. 131(2). PMID: 33463550
Bob Farese Jr. is an expert in how lipid synthesis and storage may lead to disease—and an accomplished amateur photographer.
Quick updates about the latest public health news from across the School and beyond.
For immediate release: April 13, 2020 Boston, MA – Disrupting the production of a class of lipids known as sphingolipids in neurons improved symptoms of neurodegeneration and increased survival in a mouse model, according to new research led…
November 27, 2019—Scientists across Harvard T.H. Chan School of Public Health got a major upgrade to their toolbox this week with the official launch of the Harvard Chan Advanced Multi-omics Platform, or ChAMP. Housed in the Department of…
For immediate release: April 4, 2019 New research led by Harvard T.H. Chan School of Public Health has identified numerous genes that influence how cells respond to saturated fatty acids. Some of these genes have promise as potential…