AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex.
de Polo A, Luo Z, Gerarduzzi C, Chen X, Little JB, Yuan ZM.
J Mol Cell Biol. 2017 04 01. 9(2):154-165. PMID: 27927748
Overview
Yuan Laboratory Research Focus:
The cellular responses to stress in general, and to radiation in particular, are highly coordinated processes, which, when deregulated, may contribute to the development of stress-associated pathologies and diseases including aging, diabetes and cancer. Our research focuses on elucidation of signaling mechanisms that regulate cellular stress responses and on examining how stress signals affect cell behaviors in the context of cancer. Our long term goal is to gain a better understanding of the biology of carcinogenesis, which would then allow us to design effective strategies for prevention, early detection, and treatment of cancer.
Bibliography
Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.
Gerarduzzi C, de Polo A, Liu XS, El Kharbili M, Little JB, Yuan ZM.
J Biol Chem. 2016 Dec 09. 291(50):25937-25949. PMID: 27777309
p53 coordinates with ?133p53 isoform to promote cell survival under low-level oxidative stress.
Gong L, Pan X, Yuan ZM, Peng J, Chen J.
J Mol Cell Biol. 2016 Feb. 8(1):88-90. PMID: 26705306
ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.
Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM.
Mol Cancer Res. 2015 Aug. 13(8):1206-17. PMID: 25995384
Glycolytic metabolism influences global chromatin structure.
Liu XS, Little JB, Yuan ZM.
Oncotarget. 2015 Feb 28. 6(6):4214-25. PMID: 25784656
ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis.
Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM.
Genes Dev. 2014 Sep 01. 28(17):1917-28. PMID: 25184678
A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection.
Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM.
J Biol Chem. 2014 Feb 21. 289(8):5340-7. PMID: 24391088
Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant.
Tsai KK, Stuart J, Chuang YY, Little JB, Yuan ZM.
Radiat Res. 2009 Sep. 172(3):306-13. PMID: 19708779
Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation.
Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM.
Cancer Res. 2008 Nov 15. 68(22):9131-6. PMID: 19010883
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding.
Lopez-Pajares V, Kim MM, Yuan ZM.
J Biol Chem. 2008 May 16. 283(20):13707-13. PMID: 18356162
News
Symposium explores health lessons learned from the pandemic
The John B. Little Symposium focused on lessons learned from the COVID-19 pandemic and how to better apply them to the next major disease outbreak.
Symposium honors the life and work of the late John B. Little
More than 200 people gathered virtually on October 30, 2020 for the 23rd annual John B. Little Symposium to honor the legacy of radiobiology expert John B. Little and to share research on the health effects of radiation.
Symposium gathers experts on oxidative stress and mitochondria
October 29, 2015 — Cutting-edge work on molecular mechanisms involved in the cellular response to stress was the focus at the 18th annual John B. Little Symposium, held October 23-24, 2015 at Harvard T.H. Chan School of Public Health.…
Symposium explores cancer stem cells and tumor metabolism
November 16, 2012 -- An emerging area of science is looking at not just how low-dose radiation harms cells, but also how cells respond to deal with this stress—and how science might harness those same mechanisms to benefit human…
