Ryan McCarthy

Research Fellow

Department of Genetics and Complex Diseases

IMG_6626

Education:

Ph.D. Biochemistry 2014, State University of New York at Buffalo, Buffalo NY

B.S. Biomedical Sciences 2009, State University of New York at Buffalo, Buffalo NY

Publications:

McCarthy RC and Kosman DJ (2014). Iron transport across the blood-brain barrier; development, neurovascular regulation and cerebral amyloid angiopathy. Cell Mol Life Sci. (Paper in press).

McCarthy RC and Kosman DJ (2014). Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring brain endothelia-derived interleukins in an in vitro blood-brain barrier model system. Cell Commun Signal 12(1):65.

McCarthy RC, Park Yun-hee, Kosman DJ (2014). sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep 15(7):809-15.

McCarthy RC and Kosman DJ (2014). Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS ONE 9(2): e89003.

McCarthy RC and Kosman DJ (2013). Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux. J Biol Chem 288, 17932-17940.

McCarthy RC and Kosman DJ (2012). Mechanistic analysis of iron accumulation by endothelial cells of the BBB. Biometals 25(4):665-75.

Ziegler L, Turzulli A, Gaur R, McCarthy R, Kosman DJ (2011). Functional characterization of the ferroxidase, permease high-affinity iron transport complex from Candida albicans. Mol Microbiol 81(2):473-85.

E-mail:

rmccarth@hsph.harvard.edu