About Shuji Ogino

Chief, Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital

Professor of Pathology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School

Professor in the Department of Epidemiology, Harvard T.H. Chan School of Public Health

Associate Member, Broad Institute of MIT and Harvard

NCI R35 Outstanding Investigator Award (OIA) recipient (the first cohort 2015-2022)

Shuji Ogino, MD, Ph.D
Photo by Sam Ogden

Here is my blog in Japanese:
ogino-mpe.org/                                                           

One of the most prominent features of myself is an unconventional innovative way of life.  For example, please look at the keyboard on the right where keys are programmable and can be rearranged.  I name this arrangement “smartly modified Dvorak in Kinesis”.   I have been using this type of keyboard for over 15 years to increase my productivity.  I decided not to use the QWERTY (regular) key arrangement because many major keys are not conveniently arranged, and is so inefficient.  In my own special arrangement (“modified Dvorak”), my left fingers have “a – o – e – i (and u)” as home positions, and my right fingers have “(r and) h – t – n – s” as home positions; note these are the most commonly used letters.  Please examine the keyboard above carefully.  I thank Kinesis for manufacturing these types of keyboards!

This is a very efficient keyboard, but the only issue I have is that I have to carry this keyboard whenever I travel.

 

Narrative bio:
I am a pathologist and “molecular pathological epidemiologist (MPE-ist)” with a major research effort and 20% clinical effort in molecular diagnostics / molecular genetic pathology.  Currently, I am the only unique faculty member who holds appointments in both Pathology and Epidemiology at Harvard University.  I have played various major leadership roles in international and national societies.  I have received prestigious awards and honors as listed below.

With unique combined expertise in both molecular pathology and epidemiology, I have been developing integrative interdisciplinary science of “Molecular Pathological Epidemiology (MPE)”, which is defined as “epidemiology of molecular pathology and heterogeneity of disease”.  I have been conducting MPE research with a particular focus on colorectal carcinoma.  My own research program has continuously been funded by NIH.  Recent highlights of my MPE research include two studies published in The New England Journal of Medicine (NEJM), which examined colonoscopy screening and molecular features of colorectal cancer (R Nishihara et al. 2013), and interactive effects of aspirin and PIK3CA mutation in colorectal cancer (X Liao et al. 2012).  The MPE paradigm has internationally been accepted, and the use of the MPE term has become widespread.  I established “The International MPE Meeting Series” in 2013, and have been the Chairperson of its Program Committee.  “The Second International MPE Meeting” went very successfully, with over 20 expert speakers and over 150 attendees from 16 countries and 21 U.S. States (on December 4 and 5 in 2014).  In addition to the establishment of the new field of MPE, I have been very innovative in research and have created novel paradigms, concepts and research framework, such as the “GWAS-MPE Approach” (S Ogino et al. Gut 2011), the “Unique Tumor Principle” (S Ogino et al. Expert Rev Mol Diagn 2012), the “Colorectal Continuum” model (M Yamauchi et al. Gut 2012), the “Unique Disease Principle” (S Ogino et al. Mod Pathol 2013), the “Etiologic Field Effect” concept (P Lochhead et al. Mod Pathol 2015), the “integrative lifecourse epidemiology – MPE” (lifecourse-MPE) model (A Nishi et al. Am J Prev Med 2015), the “social MPE” model (A Nishi et al. Expert Rev Mol Diagn 2015), the “immuno-MPE” model (S Ogino et al. Epidemiology 2016) and the “pharmaco-MPE” model (S Ogino et al. Epidemiology 2016).  I have also been very active in creating new research collaboration initiatives, including “MPE Working Group”, and “STROBE-MPE Initiative” (S Ogino et al. Am J Epidemiol 2012).

With my unique combination of expertise in both molecular pathology and epidemiology, I have been teaching integration of molecular and population science at Harvard Medical School and affiliated hospitals, and Harvard T.H. Chan School of Public Health.  I have served as a mentor for trainees with a wide variety of backgrounds in my interdisciplinary MPE laboratory, including pathologists, gastroenterologists, surgeons, epidemiologists, nutrition scientists, biostatisticians, and computational biologists.In addition, I regularly give a lecture for pathology residents and fellows as a part of molecular diagnostics lecture series.

At Harvard T.H. Chan School of Public Health, I am a faculty member of Master of Science Program in Computational Biology and Quantitative Genetics (CBQ) directed by Dr. John Quackenbush https://www.hsph.harvard.edu/sm-computational-biology/faculty/; Cancer Epidemiology and Cancer Prevention Track headed by Dr. Lorelei Mucci https://www.hsph.harvard.edu/cecp/members/faculty/; and Clinical Epidemiology https://www.hsph.harvard.edu/clinical-epi/faculty/

In summary, my research contribution has been very unique in integrating molecular pathology and population sciences as MPE, and has demonstrated widespread impact on biomedical and public health sciences.  In February 2015, I got promoted to Professor of Pathology at Harvard Medical School, and then to Professor in the Department of Epidemiology at Harvard T.H. Chan School of Public Health.  My next goal is to become the first “Professor of Molecular Pathological Epidemiology (MPE)”.

List of Awards and Honors (Selected)
1999 Designee for CAP Foundation Scholar’s Award
1999 Resident Seminar Competition Finalists Award, from Ohio Society of Pathologists
2000 Pulmonary Pathology Society Pathologist-in-Training Award
2004 Executive Officer’s Award, from Association for Molecular Pathology (AMP)
2011 Ramzi Cotran Young Investigator Award, from United States and Canadian Academy of Pathology (USCAP)
2012 Meritorious Service Award, from Association for Molecular Pathology (AMP)
2014-present Elected Member, American Society for Clinical Investigation (ASCI)
2014 The Best of AACR Journals (selected as the corresponding author)
2014 “The Most Influential Scientific Minds: 2014″ by Thomson Reuters
2014-present Member, FASEB (Federation of American Societies for Experimental Biology) Excellence in Science Award Committee
2015 “The Most Influential Scientific Minds: 2015” and Highly Cited Researchers, by Thomson Reuters
2015-present Recipient of NCI R35 Outstanding Investigator Award http://grantome.com/grant/NIH/R35-CA197735-01
2016 Highly Cited Researcher, by Thomson Reuters
2017 Highly Cited Researcher, by Clarivate Analytics
2018 Highly Cited Researcher, by Clarivate Analytics
2018 Runner-up for the Mentor-of-the-Year Award, Dana-Farber Cancer Institute
2018 Outstanding Investigator Award from American Society for Investigative Pathology (ASIP) (award lecture given at EB/ASIP Meeting in San Diego in April 2018)
2019-present Primary member of OPTIMISTICC Team of Cancer Research UK’s Grand Challenge
2019 Highly Cited Researcher, by Clarivate Analytics
2019 Invited nominator for Nobel Prize in Physiology or Medicine 2019
2020 Invited nominator for Nobel Prize in Physiology or Medicine 2020

Education
1993 (MD) University of Tokyo
2001 (PhD) University of Tokyo
2010 (MS in Epidemiology) Harvard T.H. Chan School of Public Health

Hospital and academic appointments, and other roles
1994-1995     Intern (Japanese Physicians Medical Education Program), U.S. Naval Hospital Okinawa, Japan
1995-1997     Resident in Pathology, Allegheny General Hospital, Drexel University, Pittsburgh, PA (I met with and was tremendously influenced by Dr. Takanori Fukushima, who has been a renowned neurosurgeon with “god hands”. http://en.wikipedia.org/wiki/Takanori_Fukushima)
1997-1999     Resident in Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH (I did research in the lab of Dr. Sanford D Markowitz, and befriended fellow lab member Dr. William Grady)
1999-2001     Molecular Pathology Fellow (Fellowship Director, Dr. Debra Leonard) and Postdoctoral Fellow (in the lab of Dr. Robert B Wilson), University of Pennsylvania Medical Center, Philadelphia, PA
2001-2004     Instructor in Pathology, Harvard Medical School, Dana-Farber Cancer Institute, and Brigham and Women’s Hospital, Boston, MA
2001-             Pathologist, Brigham and Women’s Hospital
2003-             Member, Dana-Farber Harvard Cancer Center (Cancer Immunology Program, Cancer Epidemiology Program)
2004-2008    Assistant Professor of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, and Brigham and Women’s Hospital
2008-2015    Associate Professor of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, and Brigham and Women’s Hospital
2012-2015    Associate Professor, Department of Epidemiology, Harvard T.H. Chan School of Public Health
2012-            Principal Investigator, The Molecular Pathological Epidemiology Laboratory (The MPE Lab)
2012-             Leader, The Molecular Pathological Epidemiology (MPE) Working Group
2013-             Chairperson, The International Molecular Pathological Epidemiology (MPE) Meeting Series
2015-             Professor of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, and Brigham and Women’s Hospital
2015-             Professor in the Department of Epidemiology, Harvard T.H. Chan School of Public Health
2016-             Chief, Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital
2017-             Associate Member, Broad Institute of MIT and Harvard