Ph.D., 2007, Yale University
M.Sc., 1997, Birla Institute of Technology and Science, India
I am interested in using mice as a model system to study and validate targets involved in human diseases. I am currently using mouse models to investigate pathways involving the products of the tumor suppressor genes TSC1 and TSC2 that are mutated in the tumor syndrome Tuberous Sclerosis Complex (TSC). Some of the areas my research is addressing are: 1) in vivo regulation of the TSC1-2 complex by upstream factors, such as Akt, 2) the physiological role of the TSC1-2 complex in different tissues, and 3) the genetic relationship between the TSC genes and other tumor suppressors.
Suchithra Menon and Brendan D. Manning. Common corruption of the mTOR signaling network in human tumors. Oncogene 2009 27:S43-51.
Suchithra Menon, Hongbo Chi, Huiyong Zhang, Xing Wang Deng, Richard Flavell & Ning Wei. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nature Immunology 2007 Nov;8(11):1236-45.
Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N., Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation accumulation of p53 and cyclin E, and early embryonic death. Molecular and Cellular Biology 2003 Oct;23(19):6790-7.
Yang X*, Menon S*, Lykke-Andersen K, Tsuge T, Di Xiao, Wang X, Rodriguez-Suarez RJ, Zhang H, Wei N., The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Current Biology 2002 Apr 16;12(8):667-72. *Co-1st author