Selected Publications

Burkewitz, K., Morantte, I., Weir, H. J. M., Yeo, R., Zhang, Y., Huynh, F. K., Ilkayeva., O. R., Hirschey, M. D., Grant, A. R., and Mair., W. B. Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell. 160(5): 842-855. Download full article here until April 17 2015.

Hine, C., Harputlugil, E., Zhang, Y., Ruckenstuhl, C., Lee, B. C., Brace, L., Longchamp, A., Trevino-Villarreal, J. H., Mejia, P., Ozaki, C. K., Wang, R., Gladyshev, V. N., Madeo, F., Mair, W. B., and Mitchell, J. R. Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits. Cell. 2014. 160(1-2): 132-144.

Hwang, A. B., Ryu, E., Artan, M., Chang, H., Kabir, M. H., Nam, H., Lee, D., Yang, J., Kim, S., Mair, W. B., Lee, C., Lee, S. S., and Lee, S. 2014. Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C. elegansPNAS. 2014. 111(42): E4458-4467.

Burkewitz, K., Zhang, Y., and Mair, W. B. (2014). AMPK at the nexus of energetics and aging. Cell Metabolism. Jul 1;20(1):10-25.

Heintz, C. and Mair, W. (2014). You Are What You Host: Microbiome Modulation of the Aging Process. Cell 156. 408-411

Mair, W.  (2013). Tipping the energy balance toward longevity. Cell Metabolism. 17(1):5-6.

Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., and Dillin, A. (2011). Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470, 404–U179.

Mair W, Steffen KK, Dillin A. (2011). SIP-ing the elixir of youth. Cell. 16;146(6):859-60.

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., Asara, J.M., Fitzpatrick, J., Dillin, A., Viollet, B., Kundru, M., Hansen, M., Shaw, R. J. (2011). Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331, 456–461.

Mair, W., McLeod, C. J., Wang, L., and Jones, D. L. (2010). Dietary restriction enhances germline stem cell maintenance. Aging Cell 9, 916–918.

Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U, and Hetzer, M.W. (2010). Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes. Cell. 140 (3) 372-383.

Mair, W., Panowski, S., Shaw, R.J. and Dillin, A. (2009). Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegansPLoS ONE 4:e4535.

Mair, W., and Dillin, A. (2008). Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77, 727–754.

Mair, W., Piper, M. D. W., and Partridge, L. (2005). Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol 3, e223.

Partridge, L., Piper, M.D. and Mair, W. (2005). Dietary Restriction in DrosophilaMech Ageing Dev. 126:938-950.

Mair, W., Sgro, C.M., Johnson, A.P., Chapman, T. and Partridge, L. (2004). Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogensis or ovarian activity. Exp Geron 39:1011-1019.

Mair, W., Goymer, P., Pletcher, S. D., and Partridge, L. (2003). Demography of dietary restriction and death in Drosophila. Science 301, 1731–1733.