Selected Publications

A systems approach to reverse engineer lifespan extension by dietary restriction.
Hou, L, Wang D, Chen D, Liu Y, Zhang Y, Cheng H, Xu C, Sun N, McDermott J, Mair WB, Han JDJ.
Cell Metab. 2016. In press

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness.
Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kong X, Hyde AL, Gangl MR, Mair WB, Lee CH.
Cell Metab. 2015 Oct 6;22(4):709-20. doi: 10.1016/j.cmet.2015.08.006. Epub 2015 Sep 10.

Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB.
Cell. 2015 Feb 26;160(5):842-55. doi: 10.1016/j.cell.2015.02.004.

Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR.
Cell. 2015 Jan 15;160(1-2):132-44. doi: 10.1016/j.cell.2014.11.048. Epub 2014 Dec 23.

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.
Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ.
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4458-67. doi: 10.1073/pnas.1411199111. Epub 2014 Oct 6.

AMPK at the nexus of energetics and aging.
Burkewitz K, Zhang Y, Mair WB.
Cell Metab. 2014 Jul 1;20(1):10-25. doi: 10.1016/j.cmet.2014.03.002. Epub 2014 Apr 10. Review.

You are what you host: microbiome modulation of the aging process.
Heintz C, Mair W.
Cell. 2014 Jan 30;156(3):408-11. doi: 10.1016/j.cell.2014.01.025. Review.

Tipping the energy balance toward longevity.
Mair W.
Cell Metab. 2013 Jan 8;17(1):5-6. doi: 10.1016/j.cmet.2012.11.011.

SIP-ing the elixir of youth.
Mair W*, Steffen KK, Dillin A*.
Cell. 2011 Sep 16;146(6):859-60. doi: 10.1016/j.cell.2011.08.026. *Co-corresponding Authors

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A.
Nature. 2011 Feb 17;470(7334):404-8. doi: 10.1038/nature09706.

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ.
Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23.

Dietary restriction enhances germline stem cell maintenance.
Mair W*, McLeod CJ*, Wang L, Jones DL.
Aging Cell. 2010 Oct;9(5):916-8. doi: 10.1111/j.1474-9726.2010.00602.x. *Co-first Authors

Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.
Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW.
Cell. 2010 Feb 5;140(3):372-83. doi: 10.1016/j.cell.2009.12.054.

Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
Mair W*, Panowski SH, Shaw RJ, Dillin A*.
PLoS One. 2009;4(2):e4535. doi: 10.1371/journal.pone.0004535. Epub 2009 Feb 20. *Co-corresponding Authors

Aging and survival: the genetics of life span extension by dietary restriction.
Mair W, Dillin A.
Annu Rev Biochem. 2008;77:727-54. doi: 10.1146/annurev.biochem.77.061206.171059. Review.

The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila.
Magwere T, Goodall S, Skepper J, Mair W, Brand MD, Partridge L.
J Gerontol A Biol Sci Med Sci. 2006 Jan;61(1):36-47.

Calories do not explain extension of life span by dietary restriction in Drosophila.
Mair W, Piper MD, Partridge L.
PLoS Biol. 2005 Jul;3(7):e223. Epub 2005 May 31.

Counting the calories: the role of specific nutrients in extension of life span by food restriction.
Piper MD, Mair W, Partridge L.
J Gerontol A Biol Sci Med Sci. 2005 May;60(5):549-55. Review

Dietary restriction in Drosophila.
Partridge L, Piper MD, Mair W.
Mech Ageing Dev. 2005 Sep;126(9):938-50. Review.

Dietary restriction, mortality trajectories, risk and damage.
Partridge L, Pletcher SD, Mair W.
Mech Ageing Dev. 2005 Jan;126(1):35-41. Review.

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster.
Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L.
Exp Gerontol. 2004 Aug;39(8):1137-43.

Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity.
Mair W, Sgrò CM, Johnson AP, Chapman T, Partridge L.
Exp Gerontol. 2004 Jul;39(7):1011-9.

Demography of dietary restriction and death in Drosophila.
Mair W, Goymer P, Pletcher SD, Partridge L.
Science. 2003 Sep 19;301(5640):1731-3.