Selected Publications

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.

Statzer C, Meng J, Venz R, Bland M, Robida-Stubbs S, Patel K, Petrovic D, Emsley R, Liu P, Morantte I, Haynes C, Mair WB, Longchamp A, Filipovic MR, Blackwell TK, Ewald CY. PMID: 35181679 

FLN-1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue.
Kelley CA, Triplett O, Mallick S, Burkewitz K, Mair WB, Cram EJ. Cytoskeleton (Hoboken). 2020 Sep 24. doi: 10.1002/cm.21633. Online ahead of print. PMID: 32969593

Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis.
Burkewitz K, Feng G, Dutta S, Kelley CA, Steinbaugh M, Cram EJ, Mair WB. Cell Rep. 2020 Sep 8;32(10):108125. doi: 10.1016/j.celrep.2020.108125. PMID: 32905769

Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience.
Perez-Matos MC, Mair WB. PLoS Genet. 2020 Jul 9;16(7):e1008833. doi: 10.1371/journal.pgen.1008833. eCollection 2020 Jul. PMID: 32644994

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
Smith HJ, Sharma A, Mair WB. Dev Cell. 2020 Jul 20;54(2):196-211. doi: 10.1016/j.devcel.2020.06.011. Epub 2020 Jul 2. PMID: 32619405 Review.

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30.
Liu YJ, McIntyre RL, Janssens GE, Williams EG, Lan J, van Weeghel M, Schomakers B, van der Veen H, van der Wel NN, Yao P, Mair WB, Aebersold R, MacInnes AW, Houtkooper RH. J Cell Biol. 2020 Jun 1;219(6):e201907067. doi: 10.1083/jcb.201907067. PMID: 32259199

Alternative splicing in aging and longevity.
Bhadra M, Howell P, Dutta S, Heintz C, Mair WB. Hum Genet. 2019 Dec 13. doi: 10.1007/s00439-019-02094-6. [Epub ahead of print] Review.

Causal roles of mitochondrial dynamics in longevity and healthy aging.
Sharma A, Smith HJ, Yao P, Mair WB. EMBO Rep. 2019 Dec 5;20(12):e48395. doi: 10.15252/embr.201948395. Epub 2019 Oct 31. Review.

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans.
Zhang Y, Lanjuin A, Chowdhury SR, Mistry M, Silva-García CG, Weir HJ, Lee CL, Escoubas CC, Tabakovic E, Mair WB. Elife. 2019 Aug 14;8. pii: e49158. doi: 10.7554/eLife.49158.

Single-Copy Knock-In Loci for Defined Gene Expression in Caenorhabditis elegans.
Silva-García CG, Lanjuin A, Heintz C, Dutta S, Clark NM, Mair WB. G3 (Bethesda), 2019. 2019 Jul 9;9(7):2195-2198. doi: 10.1534/g3.119.400314.

Deregulation of CRTCs in Aging and Age-Related Disease Risk: (Trends in Genetics, 33, 303-321, 2017).
Escoubas CC, Silva-García CG, Mair WB. Trends Genet. 2018 Apr;34(4):326. doi: 10.1016/j.tig.2018.01.008. Epub 2018 Mar 7. No abstract available.

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.
Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, Laboy R, Hirschey MD, Mair WB.
Cell Metabolism. 2017 Dec 5;26(6):884-896.e5. doi: 10.1016/j.cmet.2017.09.024. Epub 2017 Oct 26.

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.
Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A.
Nature. 2017 Apr 13;544(7649):185-190. doi: 10.1038/nature21686. Epub 2017 Apr 5.

Deregulation of CRTCs in Aging and Age-Related Disease Risk.
Escoubas CC, Silva-García CG, Mair WB.
Trends Genet. 2017 Mar 29. pii: S0168-9525(17)30036-7. doi: 10.1016/j.tig.2017.03.002. Epub ahead of print. Review.

Splicing Factor 1 Modulates Dietary Restriction and TORC1 Pathway Longevity in C. elegans.
Heintz C, Doktor TK, Lanjuin A, Escoubas CC, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS and Mair WB.
Nature. 2017 Jan 5;541(7635):102-106. doi: 10.1038/nature20789. Epub 2016 Dec 5.

Dietary Restriction in C. elegans
Zhang Y, Mair WB.
EXS2016. Ageing: Lessons from C. elegans; 355-391

AMPK as a Pro-longevity Target.
Burkewitz K, Weir HJ, Mair WB.
EXS. 2016. AMP-activated Protein Kinase. 107:227-256. PDF

Snapshot: Neuronal regulation of aging
Weir, HJ. and Mair WB
Cell. 2016 Jul 28;166(3):784-784.e1. doi: 10.1016/j.cell.2016.07.02

A systems approach to reverse engineer lifespan extension by dietary restriction.
Hou, L, Wang D, Chen D, Liu Y, Zhang Y, Cheng H, Xu C, Sun N, McDermott J, Mair WB, Han JDJ.
Cell Metab. 2016 Mar 8;23(3):529-40. doi: 10.1016/j.cmet.2016.02.002.

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness.
Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kong X, Hyde AL, Gangl MR, Mair WB, Lee CH.
Cell Metab. 2015 Oct 6;22(4):709-20. doi: 10.1016/j.cmet.2015.08.006. Epub 2015 Sep 10.

Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB.
Cell. 2015 Feb 26;160(5):842-55. doi: 10.1016/j.cell.2015.02.004.

Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR.
Cell. 2015 Jan 15;160(1-2):132-44. doi: 10.1016/j.cell.2014.11.048. Epub 2014 Dec 23.

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.
Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ.
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4458-67. doi: 10.1073/pnas.1411199111. Epub 2014 Oct 6.

AMPK at the nexus of energetics and aging.
Burkewitz K, Zhang Y, Mair WB.
Cell Metab. 2014 Jul 1;20(1):10-25. doi: 10.1016/j.cmet.2014.03.002. Epub 2014 Apr 10. Review.

You are what you host: microbiome modulation of the aging process.
Heintz C, Mair W.
Cell. 2014 Jan 30;156(3):408-11. doi: 10.1016/j.cell.2014.01.025. Review.

Tipping the energy balance toward longevity.
Mair W.
Cell Metab. 2013 Jan 8;17(1):5-6. doi: 10.1016/j.cmet.2012.11.011.

SIP-ing the elixir of youth.
Mair W*, Steffen KK, Dillin A*.
Cell. 2011 Sep 16;146(6):859-60. doi: 10.1016/j.cell.2011.08.026. *Co-corresponding Authors

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A.
Nature. 2011 Feb 17;470(7334):404-8. doi: 10.1038/nature09706.

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ.
Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23.

Dietary restriction enhances germline stem cell maintenance.
Mair W*, McLeod CJ*, Wang L, Jones DL.
Aging Cell. 2010 Oct;9(5):916-8. doi: 10.1111/j.1474-9726.2010.00602.x. *Co-first Authors

Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.
Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW.
Cell. 2010 Feb 5;140(3):372-83. doi: 10.1016/j.cell.2009.12.054.

Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
Mair W*, Panowski SH, Shaw RJ, Dillin A*.
PLoS One. 2009;4(2):e4535. doi: 10.1371/journal.pone.0004535. Epub 2009 Feb 20. *Co-corresponding Authors

Aging and survival: the genetics of life span extension by dietary restriction.
Mair W, Dillin A.
Annu Rev Biochem. 2008;77:727-54. doi: 10.1146/annurev.biochem.77.061206.171059. Review.

The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila.
Magwere T, Goodall S, Skepper J, Mair W, Brand MD, Partridge L.
J Gerontol A Biol Sci Med Sci. 2006 Jan;61(1):36-47.

Calories do not explain extension of life span by dietary restriction in Drosophila.
Mair W, Piper MD, Partridge L.
PLoS Biol. 2005 Jul;3(7):e223. Epub 2005 May 31.

Counting the calories: the role of specific nutrients in extension of life span by food restriction.
Piper MD, Mair W, Partridge L.
J Gerontol A Biol Sci Med Sci. 2005 May;60(5):549-55. Review

Dietary restriction in Drosophila.
Partridge L, Piper MD, Mair W.
Mech Ageing Dev. 2005 Sep;126(9):938-50. Review.

Dietary restriction, mortality trajectories, risk and damage.
Partridge L, Pletcher SD, Mair W.
Mech Ageing Dev. 2005 Jan;126(1):35-41. Review.

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster.
Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L.
Exp Gerontol. 2004 Aug;39(8):1137-43.

Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity.
Mair W, Sgrò CM, Johnson AP, Chapman T, Partridge L.
Exp Gerontol. 2004 Jul;39(7):1011-9.

Demography of dietary restriction and death in Drosophila.
Mair W, Goymer P, Pletcher SD, Partridge L.
Science.2003 Sep 19;301(5640):1731-3.