Kate is using a set of Plasmodium falciparum parasites collected from patients in Senegal over the past 17 years and their corresponding sequencing data to evaluate how antimalarial drug resistance trends in Senegal have changed over time. For her project, Kate is adapting these parasites to in vitro culturing conditions and phenotypically assessing them for drug resistance and fitness. These phenotypic assessments will determine if the changes in drug resistance mutations and their corresponding phenotypes are related to drug pressure from changes in antimalarial drug use over time in Senegal.
