Wei Yang

Visiting Scientist:

2017-2018

Education:

July 1, 1998 Bachelor of Clinical Medicine, Norman Bethune Medical Center of Jilin University, Changchun, Jilin province, China

July 1, 2005 Doctor of Radiobiology, Radiobiology Research Unit of Ministry of Health, Norman Bethune Medical Center of Jilin University.

Research Interest:

My research is focused on the elucidation of signaling pathways involved in radioresistance of normoxic or hypoxic cancer cells and cancer stem cells.

Publications:

Shen Y, Liu Y, Sun T, Yang W*. LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway. Exp Cell Res. 2017; 358 (2):188-198. *Corresponding author

Liu Y, Shen Y, Sun T, Yang W*. Mechanisms regulating radiosensitivity of glioma stem cells. Neoplasma. 2017; 64 (5): 655-665. *Corresponding author

Yang W, Yu H, Shen Y, et al. MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway. Oncotarget. 2016; 7 (27): 41505-41526.

Shi Y, Wu W, Qiao H, Yue L, Ren L, Zhang S, Yang W*, Yang Z*. The protein PprI provides protection against radiation injury in human and mouse cells. Sci Rep. 2016; 6: 26664. *Corresponding author

Wen L, Yue L, Shi Y, Ren L, Chen T, Li N, Zhang S, Yang W*, Yang Z*. Deinococcus radiodurans pprI expression enhances the radioresistance of eukaryotes. Oncotarget. 2016; 7 (13): 15339-15355. *Corresponding author

Yang W, Shen Y, Wei J, et al. MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species. Oncotarget. 2015; 6 (26): 22006-22027.

Yang W, Wei J, Guo T, et al. Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance. Exp Cell Res. 2014; 326 (1): 22-35.

Yang W, Wei J, Sun T, et al. Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice. Radiat Oncol. 2013; 8: 102.

Yang W, Sun T, Cao J, et al. Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro. Exp Cell Res, 2012, 318 (8): 944-954.

Yang W, Sun T, Cao J, et al. Hypoxia-Inducible Factor-1α Downregulation by Small Interfering RNA Inhibits Proliferation, Induces Apoptosis, and Enhances Radiosensitivity in Chemical Hypoxic Human Hepatoma SMMC-7721 Cells. Cancer Biother Radiopharm, 2011, 26 (5): 565-571.

Wei Yang, Ting Sun, Jianping Cao, et al. Survivin downregulation by siRNA/cationic liposome complex radiosensitizes human hepatoma cells in vitro and in vivo. Int J Radiat Biol, 2010, 86 (6): 445-457.

Wei Yang, Jing-Guo Zhao, Xiu-Yi Li, et al. Anti-tumor effect of 125I-UdR in combination with Egr-1 promoter-based IFNγ gene therapy in vivo. Radiation and Environmental Biophysics, 2010, 49 (4): 705-714.

Yang W, Li XY. Anti-tumor effect of pEgr-IFNγ-Endostatin gene-radiotherapy in mice bearing Lewis lung carcinoma and its mechanism. Chin Med J, 2005, 118 (4): 296-301.

Email: weyang@hsph.harvard.edu