Youyou Zhou

Visiting PhD student 

2018-Present

Assistant editor – Journal of Xiangya Medicine

Education

2017 – Present: PhD candidate
Department of Dermatology, Xiangya Hospital, Central South University, China

2015 – 2017: Research assistant
Hunan Key Laboratory of Skin Cancer and Psoriasis, Department of Dermatology, Xiangya Hospital, Central South University, China

2012 –2015: Dermatology, Master’s degree
Dalian Medical University, China

2007 –2012: Clinical medicine, Bachelor’s degree
Hubei University for Nationalities,  China

Research Interest

Small molecule inhibitors, p53, melanoma, psoriasis, arsenic

Publications/Conference Proceedings

  1. Youyou Zhou, Yanfu Wang, Juan Su, Zheng Wu, Chao Wang, Weiming Zhong, Xiaomei Liu, Linhui Cui, Xiaoyu Zhou, Yufang Ma, Yi Xin, Jianglin Zhang, Lisha Wu, Xing Hu, Xiang Chen, Cong Peng and Mingyang Gao.Integration of microRNAome, proteomics and metabolomics to analyze arsenic-induced malignant cell transformation.2017 Jun 27;8(53):90879-90896.
  2. Y Zhou, Zeng W, Qi M, Duan Y, Su J, Zhao S, Zhong W, Gao M, Li F, He Y, Hu X, Chen X, Peng C and Zhang J. Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes. Oncogenesis, 2017 Aug7;6(8):e370.
  3. Xing Hu, Juan Su, Youyou Zhou, Xiaoyun Xie, Cong Peng, Zhi-Min Yuan, Xiang Chen. Repressing CD147 is a Novel Therapeutic Strategy for Malignant Melanoma. Oncotarget, 017 Apr 11;8(15):25806-25813.
  4. Jianglin Zhang, Lei Zhou, Zunnan Huang, Xu Zhang, Youyou Zhou, Zhongling Luo, Weiqi Zeng, Juan Su, Cong Peng, Xiang Chen. Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity. Oncotarget, 2016 Nov 29;7(48):79557-79571.
  5. Youyou Zhou, Mingyang Gao. Changes of heat-shock protein 27 in arsenic-induced HaCaT malignant transformed cells, The Chinese Journal of Dermatovenereology, 2015, 29 (10): 122-124.
  6. Youyou Zhou, Xiaohong Yu, Zhiqi Song, Mingyang Gao. One case of  skin metastasis after bilateral breast cancer ,  The Chinese Journal of Dermatovenereology, 2016, 30 (2) 90-91.
  7. Youyou Zhou, Zheng Wu ,Wei Chen , Linhui Cui , Ming Yang Gao.Cyclin D1 in arsenic-induced HaCaT cell malignant transformation process and its significance.The 20th Annual Meeting of Chinese Society of Dermatology, May 2 – June 1, 2014, Hangzhou, China.
  8. Xiaodong Han, Youyou Zhou, Siwen Zheng, Zhen Li, Zhiqi Song .The effect of curcumin on human melanoma A375 and C8161 cells by AKT / mTOR signaling pathway. Chinese Journal of Dermatology, 2015, 48 (6): 14-17.
  9. Youyou Zhou, Xiang Chen, Cong Peng, Ming Yang Gao. Integration of transcriptomics, proteomics and metabonomics methods to explore the mechanism of arsenic-induced malignant transformation.The 23rd Annual Meeting of Chinese Society of Dermatology,May 11-14, 2017, Chongqing, China.
  10. Youyou Zhou, Xiang Chen ,Cong Peng ,Jianglin Zhang .MDM2 regulates p53 subcellular localization to mediate arsenite-induced resistance to keratinocyte apoptosis. The 23rd Annual Meeting of Chinese Society of Dermatology,May 11-14, 2017, Chongqing, China.
  11. Cong Peng , Youyou Zhou, Xiang Chen .The preliminary study of melanoma small molecule inhibitors target CD147.The 23rd Annual Meeting of Chinese Society of Dermatology,May 11-14, 2017, Chongqing, China.
  12. Youyou Zhou, Xiang Chen, Cong Peng. Benserazide inhibits melanoma growth by targeting PKM2.The 24rd Annual Meeting of Chinese Society of Dermatology,June 21-24, 2018, Kunming, China.
  13. Cong Peng , Youyou Zhou, Xiang Chen .PKM2 is a novel targeting molecule for melanoma treatment.The 5th East Asian Dermatology Conference.June 21-24, 2018, Kunming, China.

Patent(s)

Use of Isoproterenol and its pharmaceutically acceptable salts in the preparation of antineoplastic agents.(Inventors: Xiang Chen, Cong Peng, Youyou Zhou, Zunnan Huang. Patent No. ZL 201610424131.1. Authorization announcement date: July 13, 2018. Authorization announcement number: CN 105997963B).

Project

Benserazide suppresses the growth of melanoma and overcome vemurafenib resistance
Graduate Research and Innovation Project of Central South University
Project Leader: Youyou Zhou, Project No.202221804

Honors/Awards

2018, The 2018 SCI Paper Award of the Chinese Medical Association
2018, PhD Student National Scholarship
2018, Outstanding Student of Central South University
2017, First Prize of PhD Student Academic Scholarship

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