Select Publications

1: Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD,Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev. 2014 Sep 1;28(17):1917-28. doi: 10.1101/gad.245910.114. PubMed PMID: 25184678; PubMed Central PMCID: PMC4197949.

2: Yuan B, Cheng L, Chiang HC, Xu X, Han Y, Su H, Wang L, Zhang B, Lin J, Li X, Xie X, Wang T, Tekmal RR, Curiel TJ, Yuan ZM, Elledge R, Hu Y, Ye Q, Li R. A phosphotyrosine switch determines the antitumor activity of ERβ. J Clin Invest. 2014 Aug 1;124(8):3378-90. doi: 10.1172/JCI74085. Epub 2014 Jun 24. PubMed PMID: 24960160; PubMed Central PMCID: PMC4109526.

3: Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death Differ. 2014 May;21(5):836-44. doi: 10.1038/cdd.2014.24. Epub 2014 Feb 28. PubMed PMID: 24583639; PubMed Central PMCID: PMC3978308.

4: Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM. A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. J Biol Chem. 2014 Feb 21;289(8):5340-7. doi: 10.1074/jbc.M113.531020. Epub 2014 Jan 3. PubMed PMID: 24391088; PubMed Central PMCID: PMC3931089.

5: Su H, Xu T, Ganapathy S, Shadfan M, Long M, Huang TH, Thompson I, Yuan ZM. Elevated snoRNA biogenesis is essential in breast cancer. Oncogene. 2014 Mar 13;33(11):1348-58. doi: 10.1038/onc.2013.89. Epub 2013 Apr 1. PubMed PMID: 23542174.

6: Ganapathy S, Xiao S, Seo SJ, Lall R, Yang M, Xu T, Su H, Shadfan M, Ha CS, Yuan ZM. Low-dose arsenic induces chemotherapy protection via p53/NF-κB-mediated metabolic regulation. Oncogene. 2014 Mar 13;33(11):1359-66. doi: 10.1038/onc.2013.81. Epub 2013 Mar 25. PubMed PMID: 23524579.

7: Shadfan M, Lopez-Pajares V, Yuan ZM. MDM2 and MDMX: Alone and together in regulation of p53. Transl Cancer Res. 2012 Aug;1(2):88-89. PubMed PMID: 23002429; PubMed Central PMCID: PMC3448287.

8: Xu T, Su H, Ganapathy S, Yuan ZM. Modulation of autophagic activity by extracellular pH. Autophagy. 2011 Nov;7(11):1316-22. doi: 10.4161/auto.7.11.17785. Epub 2011 Nov 1. PubMed PMID: 21997366; PubMed Central PMCID: PMC3242796.

9: Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM. The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12001-6. doi: 10.1073/pnas.1102309108. Epub 2011 Jul 5. PubMed PMID: 21730163; PubMed Central PMCID: PMC3141917.

10: Cross B, Chen L, Cheng Q, Li B, Yuan ZM, Chen J. Inhibition of p53 DNA binding function by the MDM2 protein acidic domain. J Biol Chem. 2011 May 6;286(18):16018-29. doi: 10.1074/jbc.M111.228981. Epub 2011 Mar 17. PubMed PMID: 21454483; PubMed Central PMCID: PMC3091211.

11: Chen L, Li Z, Zwolinska AK, Smith MA, Cross B, Koomen J, Yuan ZM, Jenuwein T, Marine JC, Wright KL, Chen J. MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. EMBO J. 2010 Aug 4;29(15):2538-52. doi: 10.1038/emboj.2010.140. Epub 2010 Jun 29. PubMed PMID: 20588255; PubMed Central PMCID: PMC2928696.

12: Tsai KK, Stuart J, Chuang YY, Little JB, Yuan ZM. Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radio resistant. Radiat Res. 2009 Sep;172(3):306-13. doi: 10.1667/RR1764.1. PubMed PMID: 19708779; PubMed Central PMCID: PMC2747478.

13: Wu XL, Gu MM, Huang L, Liu XS, Zhang HX, Ding XY, Xu JQ, Cui B, Wang L, Lu SY, Chen XY, Zhang HG, Huang W, Yuan WT, Yang JM, Gu Q, Fei J, Chen Z, Yuan ZM, Wang ZG. Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet. 2009 Jul;85(1):53-63. doi: 10.1016/j.ajhg.2009.06.007. PubMed PMID: 19589401; PubMed Central PMCID: PMC2706969.

14: Cai X, Yuan ZM. Stochastic modeling and simulation of the p53-MDM2/MDMX loop. J Comput Biol. 2009 Jul;16(7):917-33. doi: 10.1089/cmb.2008.0231. PubMed PMID: 19580521; PubMed Central PMCID: PMC3148126.

15: Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM. Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res. 2008 Nov 15;68(22):9131-6. doi: 10.1158/0008-5472.CAN-08-3025. PubMed PMID: 19010883; PubMed Central PMCID: PMC2717853.

16: Lopez-Pajares V, Kim MM, Yuan ZM. Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. J Biol Chem. 2008 May 16;283(20):13707-13. doi: 10.1074/jbc.M710030200. Epub 2008 Mar 20. PubMed PMID: 18356162; PubMed Central PMCID: PMC2376244.

17: Kawai H, Lopez-Pajares V, Kim MM, Wiederschain D, Yuan ZM. RING domain-mediated interaction is a requirement for MDM2’s E3 ligase activity. Cancer Res. 2007 Jul 1;67(13):6026-30. PubMed PMID: 17616658.

18: Kim MM, Wiederschain D, Kennedy D, Hansen E, Yuan ZM. Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). Oncogene. 2007 Jun 21;26(29):4209-15. Epub 2007 Feb 5. PubMed PMID: 17297477.

19: Wiederschain D, Yuan ZM. Functional inactivation of P53 as a potential mechanism of MLL leukemogenesis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Oct;31(5):617-20. PubMed PMID: 17062917.

20: Stuart JR, Gonzalez FH, Kawai H, Yuan ZM. c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. J Biol Chem. 2006 Oct 20;281(42):31290-7. Epub 2006 Aug 9. PubMed PMID: 16899465.

21: Stuart JR, Kawai H, Tsai KK, Chuang EY, Yuan ZM. c-Abl regulates early growth response protein (EGR1) in response to oxidative stress. Oncogene. 2005 Dec 8;24(55):8085-92. PubMed PMID: 16091742.

22: Tsai KK, Chuang EY, Little JB, Yuan ZM. Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Res. 2005 Aug 1;65(15):6734-44. PubMed PMID: 16061655.

23: Wiederschain D, Kawai H, Shilatifard A, Yuan ZM. Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem. 2005 Jul 1;280(26):24315-21. Epub 2005 Apr 25. PubMed PMID: 15851483.

24: Toyoshima M, Shimura T, Adiga SK, Taga M, Shiraishi K, Inoue M, Yuan ZM, Niwa O. Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes. Oncogene. 2005 May 5;24(20):3229-35. PubMed PMID: 15735681.